中文名称:

4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚

中文同义词:

4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚;MCF-7细胞株抑制剂(YL-109);2-(4-羟基-3-甲氧基苯基)苯并噻唑

英文名称:

2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE

英文同义词:

2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE;YL-109;4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol;Y109;Y-109;Y-109;Y109;4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one;4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol

CAS号:

36341-25-0

分子式:

C14H11NO2S

分子量:

257.31

EINECS号:

相关类别:

细胞生物学试剂;小分子抑制剂;小分子抑制剂，天然产物;Inhibitors

Mol文件:

36341-25-0.mol

储存条件 

Sealed in dry,2-8°C

生物活性

YL-109是新型的抗肿瘤试剂，在体内外可抑制乳腺癌细胞的生长和侵袭。

体外研究

YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells. YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells. Cell Proliferation Assay Cell Line: MCF-7 and MDA-MB-231 cells Concentration: 0.001, 0.01, 0.1, 1, 10 μM Incubation Time: 96 hours Result: Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively).

Cell Line:

MCF-7 and MDA-MB-231 cells

Concentration:

0.001, 0.01, 0.1, 1, 10 μM

Incubation Time:

96 hours

Result:

Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively).

体内研究

YL-109 (15 mg/kg; s.c. for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo. Animal Model: BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells Dosage: 15 mg/kg Administration: S.c. every 2 days for 63 days Result: Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells.

Animal Model:

BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells

Dosage:

15 mg/kg

Administration:

S.c. every 2 days for 63 days

Result:

Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells.