中文同义词:
N-({1-[(4-氯苯基)氨基]-1-氧代-2-丙基}氧基)-3,5-二(三氟甲基)苯甲酰胺;RHOA/C介导基因转录抑制剂(CCG-1423);N-[2-[(4-氯苯基)氨基]-1-甲基-2-氧代乙氧基]-3,5-二(三氟甲基)苯甲酰胺
英文同义词:
CCG-1423;N-(2-(4-Chloroanilino)-1-Methyl-2-oxoethoxy)-3,5-bis(trifluoroMethyl)benzaMide;N-(1-(4-chlorophenylaMino)-1-oxopropan-2-yloxy)-3,5-bis(trifluoroMethyl)benzaMide;N-({1-[(4-Chlorophenyl)Amino]-1-Oxo-2-Propanyl}Oxy)-3,5-Bis(Trifluoromethyl)Benzamide CCG-1423;N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)-benzamide;Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem;CCG 1423;CCG-1423;CCG1423, >98%
相关类别:
抑制剂;小分子抑制剂;细胞生物学试剂;小分子抑制剂，天然产物;Inhibitors
储存条件
Sealed in dry,Store in freezer, under -20°C
溶解度
DMSO: soluble5mg/mL, clear (warmed)
生物活性
CCG-1423是一种特定的 RhoA 通路抑制剂，能够抑制SRF介导的转录。
体外研究
CCG-1423 selectively inhibits SRF-mediated transcription activated by Rho pathway signaling, and specifically inhibits LPA-stimulated DNA synthesis. CCG-1423 also selectively inhibits the proliferation of RhoC-overexpressing melanoma cells (A375M2 and SK-Mel-147), and strongly suppresses the Rho-dependent invasion by PC-3 cells. CCG-1423 in combination with LY294002 enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. In H9c2 cells, CCG-1423 inhibits MRTF nuclear localization, and completely blocks STARS proximal reporter activity. CCG-1423, as a Rho/MRTF/SRF pathway inhibitor, also represses both matrix-stiffness and TGF-beta-induced fibrogenesis in human colonic myofibroblasts.
