中文名称:

NULL

中文同义词:

钙离子/钙调蛋白依赖激酶II(CAMKII)抑制剂(KN-93 HYDROCHLORIDE)

英文名称:

KN93 hydrochloride

英文同义词:

KN 93 hydrochloride;KN-93 (hydrochloride);KN93 hydrochloride;KN-93 HCl;CS-1449

CAS号:

1956426-56-4

分子式:

C26H30Cl2N2O4S

分子量:

0

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

Mol File

生物活性

KN-93 hydrochloride是可渗透细胞，可逆和竞争性的抑制剂钙调蛋白依赖性激酶II型 (CaMKII) 抑制剂，Ki 为370 nM。

靶点

Ki: 370 nM (CaMK-II)

体外研究

After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.