中文名称:

盐酸替吡嘧啶

中文同义词:

TIPIRACIL盐酸盐;盐酸替吡嘧啶;盐酸替比嘧啶;5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮单盐酸盐;(9CI)-5-氯-6-[(2-亚氨基-1-吡咯烷)甲基]-2,4(1H,3H)-嘧啶二酮盐酸盐;盐酸噻吡拉西;替比拉西标准品HCL;盐酸替比拉西

英文名称:

Tipiracil

英文同义词:

Tipiracil;Tipiracil (hydrochloride);2,4(1H,3H)-PyriMidinedione,5-chloro-6-[(2-iMino-1-pyrrolidinyl)Methyl] hydrochloride;5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione monohydrochloride;Tipiracil HCl;5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione,hydrochloride;5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione hydrochloride;5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)uracil hydrochloride

CAS号:

183204-72-0

分子式:

C9H12Cl2N4O2

分子量:

279.12318

EINECS号:

相关类别:

细胞生物学试剂;小分子抑制剂;小分子抑制剂，天然产物;抗肿瘤药物;中间体;Inhibitors

Mol文件:

183204-72-0.mol

熔点 

245℃ (decomposition)

储存条件 

2-8°C

形态

powder

颜色

white to beige

生物活性

Tipiracil (MA-1)是一种 thymidine phosphorylase的抑制剂，该酶可将三氟吡啶降解为三氟胸苷。它与三氟吡啶的组合可增加三氟吡啶的生物利用度。

靶点

Target Value thymidine phosphorylase ()

Target

Value

thymidine phosphorylase ()

体外研究

Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells. Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD.

体内研究