中文名称:

ML324

中文同义词:

N-(3-(二甲氨基)丙基)-4-(8-羟基喹啉-6-基)苯甲酰胺;JMJD2去甲基酶抑制剂(ML324);N-(3-(二甲胺基)丙基)-4-(8-羟基喹啉-6-基)苯甲酰胺

英文名称:

ML234

英文同义词:

ML234;ML324;ML243;N-[3-(Dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)benzamide;NCGC00183808-01;ML324(CID-44143209);CS-2198;ML-324;ML324;ML 324

CAS号:

1222800-79-4

分子式:

C21H23N3O2

分子量:

349.43

EINECS号:

相关类别:

细胞生物学试剂;小分子抑制剂，天然产物;抑制剂;Inhibitors

Mol文件:

1222800-79-4.mol

沸点 

590.1±50.0 °C(Predicted)

密度 

1.188±0.06 g/cm3(Predicted)

储存条件 

Sealed in dry,2-8°C

溶解度 

DMSO: soluble10mg/mL, clear

形态

powder

酸度系数(pKa)

4.71±0.40(Predicted)

颜色

white to light brown

生物活性

ML324是一种选择性的jumonji histone demethylase (JMJD2)抑制剂， 其对JMJD2E的IC50为920 nM。

体外研究

ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression.

体内研究

In a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation.

危险品标志 

Xn

危险类别码 

22

WGK Germany 

3