中文名称:

163847-77-6

中文同义词:

TNF-Α转换酶TACE抑制剂(TAPI-1)

英文名称:

TAPI-1

英文同义词:

HONHCOCH2CH(CH2-CH(CH3)2)CO-NAL-ALA-NHCH2CH2NH2;TAPI-1;N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-3-(2-NAPHTHYL)ALANYL-L-ALANINE 2-AMINOETHYL AMIDE;N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)--alanyl-L-alaninamide;N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE, 2-AMINOETHYL AMIDE;TNF-ALPHA PROTEASE INHIBITOR-1;N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-Alaninamide acetate salt;TAPI-1 acetate salt

CAS号:

163847-77-6

分子式:

C26H37N5O5

分子量:

499.6

EINECS号:

相关类别:

细胞生物学试剂;抑制剂

Mol文件:

Mol File

密度 

1?+-.0.06 g/cm3(Predicted)

储存条件 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

形态

powder

酸度系数(pKa)

9.17±0.20(Predicted)

颜色

white to beige

生物活性

TAPI-1 是一种 TACE (ADAM17) 抑制剂，可阻止多种细胞表面蛋白脱落。TAPI-1 也是金属蛋白酶 (MMP) 抑制剂。

靶点

TACE (ADAM17), MMP

体外研究

TAPI-1 (1 µM for 30 min) increases cell viability in LPS-treated HK-2 cells. TAPI-1 attenuates oxidative stress and inflammatory cytokines LPS treatment significantly induces renal IL-6 and TNFα mRNA expression, while these changes is attenuated with TAPI-1 pretreatment in LPS-treated HK-2 cells. Cell Viability Assay Cell Line: LPS-treated HK-2 cells Concentration: 1 µM Incubation Time: 30 minutes (pre-treated) Result: Increased cell viability.

Cell Line:

LPS-treated HK-2 cells

Concentration:

1 µM

Incubation Time:

30 minutes (pre-treated)

Result:

Increased cell viability.

危险品标志 

T

危险类别码 

25

安全说明 

45

危险品运输编号 

UN 2811 6.1 / PGIII

WGK Germany 

3