4-(2-氨乙基)苯磺酰氟盐酸盐

中文名称:

4-(2-氨乙基)苯磺酰氟盐酸盐

中文同义词:

4-(2-氨乙基)苯磺酰氟盐酸盐(AEBSF);4-(2-氨乙基)苯磺酰氟盐酸盐[用于生化研究];4-(2-氨基乙基)氟苯磺酰盐酸盐;4-(2-氨乙基)苯磺酰氟盐酸盐,97%;4-(2-氨乙基)苯磺酰氟盐酸盐;4-2-胺乙基苯磺酰氟盐酸盐;AEBSF丝氨酸抑制剂;4-(2-氨乙基)苯磺酰氟酸盐

英文名称:

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride

英文同义词:

4-(Fluorosulphonyl)phenethylamine hydrochloride, 2-[4-(Fluorosulphonyl)phenyl]ethylamine hydrochloride, AEBSF;Benzenesulfonyl fluoride, 4-(2-aMinoethyl)-, hydrochloride (1:1);4-(2-AMinoethyl)benzenesulfonyl fluoride hydrochlorid;4-(2-Aminoethyl)-benzenesulfonyl fluoride hydrochloride (1:1);BROMOPHENOL BLUE NA SALT PROTEOMICS GR;AEBSF HCI;AEBSF;AEBSF HCL

CAS号:

30827-99-7

分子式:

C8H11ClFNO2S

分子量:

239.69

EINECS号:

608-547-2

相关类别:

蛋白酶抑制剂;蛋白质组学;小分子抑制剂，天然产物;细胞裂解蛋白酶抑制剂;酶抑制剂;生化试剂;高纯试剂;ProteaseInhibitors;细胞生物学;酶类;inhibitor;Inhibitors;化学试剂;生化试剂-酶类;细胞生物学-蛋白提取/检测;原料药

Mol文件:

30827-99-7.mol

熔点 

175-177 °C

储存条件 

2-8°C

溶解度 

H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.)

形态

Powder

颜色

White

PH值

pH3.0～5.0 (10g/L, 25℃)

水溶解性 

10 g/L (20 ºC)

敏感性 

Moisture Sensitive

BRN 

7604627

InChIKey

WRDABNWSWOHGMS-UHFFFAOYSA-N

CAS 数据库

30827-99-7(CAS DataBase Reference)

生物活性

AEBSF hydrochloride 是丝氨酸蛋白酶 的不可逆抑制剂，可抑制例如胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶和胰蛋白酶。

体外研究

AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern.

体内研究

AEBSF (76.8 mg/kg daily, i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model.

用途 

建议使用浓度为0.1至1mM。

用途 

作为不可逆的丝氨酸蛋白酶抑制剂，用于细胞培养

用途 

推荐使用浓度为0.1-1 mM. 不可逆的丝氨酸蛋白酶抑制剂,抑制胰蛋白酶,糜蛋白酶,纤溶酶,凝血酶及激肽释放酶. 可溶于水,其pH7的水溶液在4oC可保持稳定1-2个月。

危险品标志 

C,Xi

危险类别码 

34-36/37/38

安全说明 

45-36/37/39-26-36

危险品运输编号 

UN 3261

WGK Germany 

3

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

II

海关编码 

29214990