苯并(a)芘

中文名称:

苯并(a)芘

中文同义词:

苯并(a)芘;3，4-苯并芘;苯并[A]芘;苯并[A]芘溶液, 20PPM;3,4-苯并芘(升华精制品)(>95.0%(GC));羟基苯并芘杂质;苯并[DET]屈;苯并[A]芘 溶液

英文名称:

Benzo[a]pyrene

英文同义词:

3,4-benz(a)pyrene;3,4-Benz[a]pyrene;3,4-Benzopirene;3,4-Benzpyren;3,4-BP;BP;coaltarpitchvolatiles:benzo(a)pyrene;Rcra waste number U022

CAS号:

50-32-8

分子式:

C20H12

分子量:

252.31

EINECS号:

200-028-5

相关类别:

苯并杂环;多环芳烃;分析标准品;生化试剂;多环芳烃类;有机碱,格氏试剂;农业和环境标准品;细胞信号和神经生物学;其他生化试剂;Industrial/Fine Chemicals;Benzo(a)pyrene and other PAH;Organics;Analytical Chemistry;Environmental Endocrine Disruptors;Estradiol, etc. (Environmental Endocrine Disruptors);Highly Purified Reagents;Other Categories;Refined Products by Sublimation;A-BAlphabetic;Alpha Sort;B;A-BAnalytical Standards;AromaticsAlphabetic;PAH;对照品;合成材料中间体;色谱纯;BA - BHEnvironmental Standards;PAHs;Volatiles/ Semivolatiles;BA - BHChemical Class;Chemical Class;Hydrocarbons;NeatsAnalytical Standards;PAHsEnvironmental Standards;PAHsMore...Close...

Mol文件:

50-32-8.mol

熔点 

177-180°C

沸点 

495°C

密度 

1.1549 (estimate)

蒸气压

2.4 at 25 °C (McVeety and Hites, 1988)

折射率 

1.8530 (estimate)

闪点 

495°C

储存条件 

2-8°C

溶解度 

Soluble in benzene, toluene, and xylene; sparingly soluble in ethanol and methanol (Windholz et al., 1983)

酸度系数(pKa)

>15 (Christensen et al., 1975)

形态

Crystalline

颜色

Pale yellow/green/orange

水溶解性 

Soluble in benzene, toluene, and xylene. Sparingly soluble in alcohol, methanol. Insoluble in water

Merck 

14,1103

BRN 

1911333

Henrys Law Constant

7.35 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)(x 10-10 mmHg at 25 °C):

稳定性

Stable. Incompatible with strong oxidizing agents.

InChIKey

FMMWHPNWAFZXNH-UHFFFAOYSA-N

CAS 数据库

50-32-8(CAS DataBase Reference)

(IARC)致癌物分类

1 (Vol. Sup 7, 92, 100F) 2012

EPA化学物质信息

Benzo[a]pyrene (50-32-8)

简介

苯并芘（Benzopyrene），它是由一个苯环和一个芘分子结合而成的多环芳烃类化合物，是一种常见的高活性间接致癌物，是目 前世界三大强致癌物之一。根据国家《食用植物油卫生标准》，食用油中 苯并芘含量的最高上限为10微克/千克。苯并[a]芘是一种具有潜在的致癌、致畸和致突变作用的5环结构多环芳烃。

危害

苯并(a)芘是世界公认的强致癌性多环芳烃污染物，这是因为其自身具有五环结构，因此能积累在生物体中，导致生物染色体发生畸变，无序合成DNA，进而威 胁到人类健康。苯并(a)芘在环境中分布很广。

生物活性

Benzo[a]pyrene 在动物模型中显示肺致癌性，并且它们经常用于化学预防研究。

体内研究

Statistically significant decrease is observed at 7 weeks in females receiving 1.0 mg Benzo[a]pyrene (B[a]P) compare with the vehicle group. As lung tumorigenesis induced by Benzo[a]pyrene is dose dependent in female A/J mice. The incidence of hyperplasia values in females treating with 0.25, 0.50, and 1.0 mg Benzo[a]pyrene are significantly higher than in the vehicle-treated group. The incidence of adenoma in females receiving 1.0 mg Benzo[a]pyrene is significantly higher than in the vehicle group. The multiplicity of hyperplasia in females receiving 0.50 or 1.0 mg Benzo[a]pyrene is significantly higher than in the vehicle group. The multiplicity of adenoma in the group treated with 1.0 mg is also significantly higher than in the vehicle group. The incidences of hyperplasia and adenoma in female A/J mice are significantly increased by Benzo[a]pyrene in a dose-dependent manner. Benzo[a]pyrene induces an average of 9.38±1.75 tumors with an average tumor load of 19.53±3.81 mm 3 (P<0.05 compare to control). Benzo[a]pyrene administration significantly (P<0.05) decreases cAMP levels in tumors with adjacent lung tissues. The expression level of PDE4D gene is also increased by Benzo[a]pyrene administration.

类别

有毒物品

毒性分级

高毒

急性毒性

皮下-大鼠 LD50: 50 毫克/公斤; 腹腔-小鼠 LDL0: 500 毫克/公斤

刺激数据

皮肤-小鼠 0.014 毫克 轻度

可燃性危险特性

可燃; 燃烧产生刺激烟雾

储运特性

通风低温干燥; 与库房食品原料分开存放

灭火剂

干粉,泡沫,沙土,二氧化碳, 雾状水

职业标准

TWA 0.2 毫克/立方米

危险品标志 

T,N,F

危险类别码 

45-46-50/53-60-61-43-67-66-36-11-65-38-52/53-36/37/38

安全说明 

45-53-61-60-26-62-16

危险品运输编号 

2811

WGK Germany 

3

RTECS号

DJ3675000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

海关编码 

29029090

毒性

LD50 for mice (intraperitoneal) 232 mg/kg (Salamone, 1981).