磺丁基-Β-环糊精

中文名称:

磺丁基-Β-环糊精

中文同义词:

磺丁基-BETA-环糊精钠盐;B-环糊精磺丁基醚钠盐;B-环糊精磺丁基醚钠盐 - USP;磺丁基倍他环糊精钠;磺丁基-Β-环糊精钠盐 5G;SODIUM SULPHOBUTYLETHER-尾-CYCLODEXTRIN;磺丁基醚倍他环糊精钠盐;磺丁基醚-Β-环糊精钠盐

英文名称:

β-Cyclodextrin, sulfobutyl ethers, sodium salts

英文同义词:

.beta.-Cyclodextrin, sulfobutyl ethers, sodium salts;SBE-β-CD(Sulfobutyl Ether-β-cyclodextrin Sodium salt);BETADEX SULFOBUTYL ETHER SOIDUM;sulfobutyl ether sodium salt;betadex sulfobuytl ether sodium;β-Cyclodextrin, sulfobutyl ethers;Sulfobutylated beta-cyclodextrin sodium salt (DS~4);Sulfobutylated beta-cyclodextrin sodium salt (DS~6)

CAS号:

182410-00-0

分子式:

C42H70O35

分子量:

1134.9842

EINECS号:

1308068-626-2

相关类别:

生化试剂-碳水化合物类;原料;碳水化合物类;环糊精类;医药中间体;医药原料;中间体;苯环类;药用辅料，增溶剂、润湿剂、螯合剂（络合剂）;原料药;医药 辅料;药用辅料;医用原料;生化试剂-蛋白质;化妆品原料;Pharmaceutical;有机中间体;生物化工品

Mol文件:

182410-00-0.mol

储存条件 

Inert atmosphere,Room Temperature

溶解度 

Soluble in water. Insoluble in acetone, methanol, chloroform.

形态

Solid powder

颜色

White to off white

用途

磺丁基醚-β-环糊精钠，是一种新型药物制剂辅料，属于阴离子型高水溶性环糊精的一种磺酸基衍生物。它能很好地与药物分子包合形成非共价复合物，提高了药物的稳定性、水溶性、安全性并且有效的提高了药物分子的生物活性它的肾毒性小，能缓和药物溶血性，控制药物释放速率。

制备

以β-环糊精和1,4-磺丁内酯为原料，通过向碱性水溶液中引入适量有机溶剂，增加了1,4-磺丁内酯的溶解度，提高了磺丁基醚-β-环糊精的合成收率；所得产品溶液经过超声透析，活性炭脱色，冷冻干燥等操作得到磺丁基醚-β-环糊精粉末产品。

生物活性

Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) 是一种新型的、化学修饰过的环糊精，具有比较好的稳定性和溶解性。

体外研究

SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range.

体内研究

20% SBE-β-CD in saline: Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). 1. Dissolve 0.9 g of NaCl in 100 mL distilled water to make a clear 0.9% saline solution. 2. Measure 2 g of dry SBE-β-CD. 3. Dissolve 2 g of SBE-β-CD in 0.9% saline to make 10 mL with a 20% (w/v) concentration. These may require ultrasonic (20-40 kHz, 30 seconds, repeat 3 times) or heating (37°C for about 30 minutes). If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use.

海关编码 

2940006000