醛固酮

中文名称:

醛固酮

中文同义词:

醛固酮溶液,100PPM;醛固醇酮;醛甾酮;醛固酮;醛固酮(+4℃);醛固酮(溶液)[干冰运输];醛固酮[干冰运输];非标记醛固酮(化学纯度95%)

英文名称:

ALDOSTERONE

英文同义词:

ELECTROCORTIN;11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al;11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al;18-Oxocorticosterone;LECTROCORTIN;REICHSTEIN X;21-dihydroxy-3,20-dioxo-1(11-beta)-pregn-4-en-18-a;21-dihydroxy-3,20-dioxo-1(11beta)-pregn-4-en-18-a

CAS号:

52-39-1

分子式:

C21H28O5

分子量:

360.45

EINECS号:

200-139-9

相关类别:

化学试剂;内分泌系列;对照品;生化试剂-其他化学试剂;细胞生物学;标准品;化工原料;Corticosteroid;Growth Factors and Hormones;Steroid Hormones;A-AM;Aldehydes;Bioactive Small Molecules;Building Blocks;C13-C60;Carbonyl Compounds;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Cytokines;Isolabel;TPI;Steroids;Intermediates Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Hormones;Organic Building Blocks

Mol文件:

52-39-1.mol

熔点 

170-172°C

比旋光度 

D23 +152.2° (anhydr; c = 2 in acetone); D25 +161° (c = 0.1 in chloroform)

沸点 

412.46°C (rough estimate)

密度 

1.28

折射率 

1.6120 (estimate)

闪点 

2℃

储存条件 

Sealed in dry,Room Temperature

酸度系数(pKa)

12.98±0.10(Predicted)

形态

Crystalline Powder

颜色

White

水溶解性 

51.18mg/L(37 ºC)

Merck 

13,224

BRN 

3224996

CAS 数据库

52-39-1(CAS DataBase Reference)

EPA化学物质信息

Aldosterone (52-39-1)

生物活性

Aldosterone 是原发性盐皮质激素。Aldosterone 是一种类固醇激素，通过肾上腺皮质的肾小球区 (ZG) 对肾素-血管紧张素系统激活 (RAS) 或高钾饮食反应而合成和分泌。Aldosterone 活性在细胞水平上依赖于胞浆/核盐皮质激素受体 (MR) 的结合和激活。

靶点

Human Endogenous Metabolite

Human Endogenous Metabolite

体外研究

Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner.

体内研究

Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP). Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase ( 14 mmHg) in blood pressure in male mice. Animal Model: Forty male Wistar rats Dosage: 1 mg/Kg (+1% NaCl) Administration: i.h.; once daily for 3 weeks Result: Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals.

Animal Model:

Forty male Wistar rats

Dosage:

1 mg/Kg (+1% NaCl)

Administration:

i.h.; once daily for 3 weeks

Result:

Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals.

类别

有毒物品

可燃性危险特性

易燃; 燃烧排放刺激烟雾

储运特性

库房通风低温干燥; 与食品添加剂分开存放

灭火剂

泡沫,沙土,二氧化碳,干粉, 雾状水

危险品标志 

Xi,Xn,F

危险类别码 

36/37/38-36-20/21/22-11

安全说明 

22-24/25-36-26-36/37-16

危险品运输编号 

UN 1648 3 / PGII

WGK Germany 

3

RTECS号

TU4523000

F 

22-24-25

海关编码 

29372900