二苯甲酰基甲烷

中文名称:

二苯甲酰基甲烷

中文同义词:

ω-苯甲酰基苯乙酮;二苯甲酰甲烷;二苯甲酰基甲烷;DIBENZOYLMETHANE英文同义词: ,3-DIPHENYL-PROPANE-1,3-DIONE;二苯甲酰基甲烷(DBM);二苯甲酰基甲烷, 97+%;1,3-二苯基丙二酮 DBM;二苯甲酰基甲烷(DMB)

英文名称:

Dibenzoylmethane

英文同义词:

,3-Diphenyl-propane-1,3-dione;1,3-Diphenyl-1,3-propanediamine;1,3-diphenyl-3-propanedione;1,3-Diphenylpropanedione;Phenyl-hydroxystyrylketone;phenylphenacylketone;rhodiastab83;DBM

CAS号:

120-46-7

分子式:

C15H12O2

分子量:

224.25

EINECS号:

204-398-9

相关类别:

细胞生物学;化工原料;有机化工;医药原料;生物活性小分子;苯甲酰;Beta二酮;酮;塑料制造;化工产品-有机化工;有机化工原料;无机化工原料;有机化工原料;日用化学品原料;其他原料;原料;大化工;化工材料;Color Former Related Compounds;Functional Materials;Sensitizer;Slight yellowish crystalline powder;化工原料-表面活性剂

Mol文件:

120-46-7.mol

熔点 

77-79 °C(lit.)

沸点 

219-221 °C18 mm Hg(lit.)

密度 

0.800 g/cm3

折射率 

1.6600 (estimate)

闪点 

219-221°C/18mm

储存条件 

Store at RT.

酸度系数(pKa)

8.95±0.10(Predicted)

形态

Crystals

颜色

Light yellow to yellow

水溶解性 

It is Soluble in ether, chloroform, and aqueous sodium hydroxide. Insoluble in water.

Merck 

14,3009

BRN 

514910

稳定性

Stable. Incompatible with strong oxidizing agents.

InChIKey

NZZIMKJIVMHWJC-UHFFFAOYSA-N

CAS 数据库

120-46-7(CAS DataBase Reference)

NIST化学物质信息

1,3-Propanedione, 1,3-diphenyl-(120-46-7)

EPA化学物质信息

1,3-Propanedione, 1,3-diphenyl- (120-46-7)

生物活性

Dibenzoylmethane 是甘草中的次要成分，可激活 Nrf2 并预防各种癌症和氧化损伤。Dibenzoylmethane 是姜黄素的类似物，会引起 Keap1 解离和 Nrf2 的核易位。

体外研究

Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h. Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells. Dibenzoylmethane does not show significant cytotoxicity.

体内研究

Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice. Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice.

化学性质 

无色斜方形片状结晶。熔点81℃，沸点219℃（2.4kPa）。易溶于氯醇、氯仿，能溶于氢氧化钠溶液，不溶于碳酸钠溶液，极微溶于水。

用途 

分析试剂，检定二硫化碳和铊，重量测定铀，光度测定U+4，萃取银、铝、钡、铍、钙、镉、钴、铜、铁、镓、汞、锢、镧、镁、锰、镍、铅、钯、钪、钍、钛、锌、锆等。

用途 

作为钙/锌羟酸盐稳定体系的共稳定剂，用来制造PVC矿泉水瓶

生产方法 

由苄叉乙酰基苯为原料，经溴化、水解得到。

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

22-24/25

WGK Germany 

3

RTECS号

TZ1930000

Hazard Note 

Irritant

TSCA 

Yes

海关编码 

29143900