四乙基氯化

中文名称:

四乙基氯化铵

中文同义词:

四乙銨化氯;四乙胺氯化物;四乙基氯化胺;四乙基氯化铵水合物;氯化四乙胺;四乙基氯化铵(TEAC);氯化四乙铵;氯化四乙基铵

英文名称:

Tetraethylammonium Chloride

英文同义词:

ETAMON CHLORIDE;TETRAETHYLAMMONIUM CHLORIDE;TEA CHLORIDE;tetraethyl-ammoniuchloride;Tetraethylammonium;TETRAETHYLAMMONIUMCHLORIDE,MONOHYDRATE,CRYSTAL,REAGENT;AMMONIUM,TETRAETHYL-,CHLORIDE;TETRAETHYLAMINEHYDROCHLORIDE

CAS号:

56-34-8

分子式:

C8H20ClN

分子量:

165.7

EINECS号:

200-267-5

相关类别:

卤代物;铵类;合成试剂;细胞信号和神经生物学;相转移催化剂;阳离子表面活性剂;quarternary ammonium salts;季胺盐系列;季铵盐;生化试剂;催化剂;化学试剂;化工中间体;中间体;生化试剂-其他化学试剂;有机化工原料;有机原料;化工原料;Ammonium Chlorides (Quaternary);Quaternary Ammonium Compounds;Ion Channels;Quaternary ammonium salt

Mol文件:

56-34-8.mol

熔点 

39°C

沸点 

273.32°C (rough estimate)

密度 

1.08

折射率 

1.5480 (estimate)

储存条件 

Store at RT

溶解度 

methanol: 0.1 g/mL, clear, colorless

形态

Crystalline Powder

颜色

white to light yellow

水溶解性 

Soluble in water, ethanol, chloroform, or acetone

最大波长(λmax)

λ: 260 nm Amax: 0.03 λ: 280 nm Amax: 0.03

敏感性 

Hygroscopic

Merck 

14,9200

BRN 

3563247

稳定性

Stable. Incompatible with strong oxidizing agents. Protect from moisture.

InChIKey

YMBCJWGVCUEGHA-UHFFFAOYSA-M

CAS 数据库

56-34-8(CAS DataBase Reference)

EPA化学物质信息

Tetraethylammonium chloride (56-34-8)

生物活性

Tetraethylammonium chloride 是一种非选择性的钾通道 (potassium channel) 阻滞剂。Tetraethylammonium chloride 是有机阳离子转运蛋白的良好底物，并具有抗肿瘤特性。

体外研究

Tetraethylammonium (0.2-60 mM; 24-72 hours; C6 and 9L glioma cells) treatment inhibits the proliferation of C6 and 9L cells in a dose- and time-dependent manner. Tetraethylammonium (40 mM; 24-72 hours; C6 and 9L glioma cells) treatment significantly increases apoptosis in cells. Tetraethylammonium (40 mM; 12-48 hours; C6 and 9L glioma cells) treatment significantly elevates Bax/Bcl-2 protein ratio in a time-dependent manner. The generation of intracellular ROS increased in C6 and 9L cells by the addition of 20 and 40 mM Tetraethylammonium. Cell Proliferation Assay Cell Line: Rat C6 and 9L glioma cells Concentration: 0.2 mM, 2 mM, 20 mM, 40 mM and 60 mM Incubation Time: 24 hours, 48 hours and 72 hours Result: Inhibited the proliferation of C6 and 9L cells in a dose- and time-dependent manner. Apoptosis Analysis Cell Line: Rat C6 and 9L glioma cells Concentration: 40 mM Incubation Time: 24 hours, 48 hours and 72 hours Result: Significantly increased apoptosis in cells. Western Blot Analysis Cell Line: Rat C6 and 9L glioma cells Concentration: 40 mM Incubation Time: 12 hours, 24 hours, 48 hours Result: The expression of Bax was markedly increased, while that of Bcl-2 showed a decreasing trend 12, 24 and 48 h.

Cell Line:

Rat C6 and 9L glioma cells

Concentration:

0.2 mM, 2 mM, 20 mM, 40 mM and 60 mM

Incubation Time:

24 hours, 48 hours and 72 hours

Result:

Inhibited the proliferation of C6 and 9L cells in a dose- and time-dependent manner.

Cell Line:

Rat C6 and 9L glioma cells

Concentration:

40 mM

Incubation Time:

24 hours, 48 hours and 72 hours

Result:

Significantly increased apoptosis in cells.

Cell Line:

Rat C6 and 9L glioma cells

Concentration:

40 mM

Incubation Time:

12 hours, 24 hours, 48 hours

Result:

The expression of Bax was markedly increased, while that of Bcl-2 showed a decreasing trend 12, 24 and 48 h.

体内研究

Tetraethylammonium (1 mM, 3 mM, and 5 mM) significantly increases the amplitude and frequency of contractility of colon and rectum from rats in longitudinal and circular direction. Tetraethylammonium at 5 mM and 15 mM concentrations shows no effect on histology of colon and rectum from rats that are administered locally with Tetraethylammonium into colon lumen from anus for 10 days.

用途 

聚合反应用相转移催化剂。膜运载研究用电解质。检验锑和铋，测定金。极谱分析用作极谱分析试剂

用途 

聚合反应用相转移催化剂。膜运载研究用电解质。检验锑和铋，测定金。极谱分析。 阻塞K+ 通道; 依靠阻断受体介导的K+流动阻断乙酰胆碱神经递质。

危险品标志 

Xn,Xi

危险类别码 

22-36/37/38

安全说明 

26-36-37/39

WGK Germany 

3

RTECS号

BS6125000

F 

3-10

TSCA 

Yes

海关编码 

29239000

毒性

LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.)