连翘脂苷B

中文名称:

连翘脂苷B

中文同义词:

连翘酯甙B;连翘酯苷B(标准品);连翘脂苷B/连翘酯苷B;连翘酯苷B;连翘脂苷B;连翘脂苷 B, 来源于广东紫珠;连翘酯苷B(连翘酯甙B);FORSYTHOSIDE B 连翘酯苷B

英文名称:

Forsythoside B

英文同义词:

Forsythoside B;(E)-O-D-Apio-beta-D-furanosyl-(1-6)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-3)]-beta-D-glucopyranoside 2-(3,4-dihydroxyphenyl)ethyl 4-[3-(3,4-dihydroxyphenyl)-2-propenoate];Forsythoside B, 98%, from Callicarpa kwangtungensis Chun;β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl O-D-apio-β-D-furanosyl-(1→6)-O-[6-deoxy-α-L-mannopyranosyl-(1→3)]-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]

CAS号:

81525-13-5

分子式:

C34H44O19

分子量:

756.7

EINECS号:

1592732-453-0

相关类别:

中药对照品;标准品;植物提取物;标准品-中药标准品;精细化工;标准品-对照品;对照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;植提标准品;竹节参皂苷Iva;其它酚类;标准品 -中药标准品;标准品，对照品

Mol文件:

81525-13-5.mol

沸点 

1040.3±65.0 °C(Predicted)

密度 

1.65

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

9.31±0.10(Predicted)

功效与作用

连翘脂苷B具有抗菌、消炎功效，主要用于治疗风热感冒、痈肿疮毒、淋巴结结核、尿路感染等症状。

生物活性

连翘脂苷B（Forsythoside B） 是从中药民间植物轮枝的叶子中分离出来的一种苯乙胺类苷。连翘脂苷B具有有效的神经保护作用，并具有抗发炎、抗氧化和防腐特性。连翘脂苷B可以抑制 TNF-alpha、IL-6、IκB 并调节 NF-κB。

靶点

Target Value TNF-alpha () IL-6 () NF-κB () IκB ()

Target

Value

TNF-alpha ()

IL-6 ()

NF-κB ()

IκB ()

体外研究

Forsythoside B concentration-dependently down-regulates the levels of TNF-α, IL-6 and high-mobility group-box 1 protein (HMGB1) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, inhibits the IκB kinase (IKK) pathway and modulated nuclear factor (NF)- κB.

体内研究

Intravenous injection of forsythoside B alone or plus imipenem reduces serum levels of TNF-α, IL-6, HMGB1, triggering receptor expressed on myeloid cells (TREM-1) and endotoxin, while the serum level of IL-10 is up-regulated and myeloperoxidase (MPO) in lung, liver and small intestine is reduced. Forsythoside B at doses higher than 8 mg/kg produces a significant neuroprotective potential in cerebral ischemia and reperfusion rats. Forsythoside B (20 mg/kg) demonstrates significant neuroprotective activity even after delayed administration at 1 h, 3 h and 5 h after cerebral ischemia and reperfusion. Forsythoside B 20 mg/kg attenuates histopathological damage as demonstrated by smaller brain infarct size and brain edema, decreased cerebral Evans blue extravasation and myeloperoxidase activity, inhibited cerebral phosphor-IκB-α and NF-κB expression. Forsythoside B shows a significant recovery in myocardial function with improvement of LVSP and +/-dp/dt(max). The myocardial infarct volume, serum levels of Tn-T, TNF-alpha and IL-6, content of MDA and MPO activity in myocardial tissue are all reduced, protein expression of HMGB1, phosphor-I kappaB-alpha and phosphor-NF-kappaB are down-regulated, while attenuate the decrease of SOD and GPx activities.

化学性质 

类白色结晶粉末，易溶于甲醇，来源于广东紫珠、叶下珠。

用途 

连翘酯苷B具有抗炎抗病毒的作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:具有抗菌、消炎、解热、治疗风热感冒、痈肿疮毒、淋巴结结核、尿路感染。

海关编码 

29389090