莫匹罗星钙(二水合物)

中文名称:

莫匹罗星钙(二水合物)

中文同义词:

莫匹罗星钙;莫匹罗星钙(二水合物);莫匹罗星钙 USP标准品

英文名称:

MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD

英文同义词:

MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD;Calcium mupirocin dihydrate;L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, calcium salt (2:1), dihydrate, [2E,8[2S,3S(1S,2S)]]- (9CI);mupirocin calcium hydrate;Calcium 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate dihydrate;Mupirocin calcium dihydrate;Mupirocin Calcium (200 mg);5,9-ANHYDRO-2,3,4,8-TETRADEOXY-8-[[3-(2-HYDROXY-1-METHYLPROPYL)OXIRANYL]METHYL]-3-METHYL-[2E,8[2S,3S(1S,2S)]]-L-TALONONO

CAS号:

115074-43-6

分子式:

C52H86CaO18.2H2O

分子量:

1075.34

EINECS号:

200-158-5

相关类别:

医药原料 抗生素;其他化工产品;其他原料;医药原料;医药化工类;原料药;医药原料药-科研原料;其他原料

Mol文件:

115074-43-6.mol

熔点 

132-139 °C

溶解度 

Very slightly soluble in water, sparingly soluble in anhydrous ethanol and in methylene chloride.

应用

莫匹罗星钙(二水合物)主要用作抗生素类医药原料。

生物活性

Mupirocin Calcium (Pseudomonic acid A)是mupirocin的钙盐形式。Mupirocin是一种天然的巴豆酸衍生物，提取自荧光假单胞菌，抑制细菌蛋白质合成，被用作一种抗生素。

体外研究

Mupirocin Calcium Salt shows a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria. Mupirocin Calcium Salt is highly bound (95% bound) to the protein of human serum, and activity was reduced 10- to 20-fold in the presence of human serum.

体内研究

Mupirocin Calcium Salt is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A.

WGK Germany 

3

海关编码 

2941906000