盐酸双环维林

中文名称:

盐酸双环维林

中文同义词:

盐酸双环维林杂质;盐酸双环胺;盐酸双环维林;双环维林盐酸盐[受控];盐酸双环胺DICYCLOVERINE HYDROCHLORIDE;双环胺盐酸盐;盐酸双环维林 USP标准品;DICYCLOVERINE HCL (DICYCLOMINE HCL)

英文名称:

DICYCLOMINE HYDROCHLORIDE

英文同义词:

[BICYCLOHEXYL]-1-CARBOXYLIC ACID DIETHYLAMINOETHYL ESTER HYDROCHLORIDE;DICYCLOMINE HCL;DICYCLOMINE HYDROCHLORIDE;LABOTEST-BB LT00771946;[1,1-BICYCLOHEXYL]-1-CARBOXYLIC ACID 2-(DIETHYLAMINO) ETHYL ESTER, HYDROCHLORIDE;(1,1’-bicyclohexyl)-1-carboxylicacid,2-(diethylamino)ethylester,hydrochlo;Dicyclomine, Hydrochloride ([1,1;[2-[[[1,1-bicyclohexyl]-1-ylcarbonyl]oxy]ethyl]diethylammonium chloride

CAS号:

67-92-5

分子式:

C19H36ClNO2

分子量:

345.95

EINECS号:

200-671-1

相关类别:

小分子抑制剂;中药对照品;标准品;Intermediates Fine Chemicals;Pharmaceuticals;BENTYL

Mol文件:

67-92-5.mol

熔点 

164-166°C

储存条件 

-20°C Freezer

溶解度 

H2O: 50 mg/mL

形态

powder

颜色

off-white

EPA化学物质信息

2-Diethylaminoethyl bicyclohexyl-1-carboxylate hydrochloride (67-92-5)

生物活性

Dicyclomine hydrochloride 是一种有效的口服活性毒蕈碱胆碱能受体 (muscarinic cholinergic receptors) 拮抗剂。Dicyclomine hydrochloride 对 M1 受体亚型 (Ki=5.1 nM) 和 M2 受体亚型 (Ki=54.6 nM) 在刷缘膜和基底质膜中均表现出较高的亲和力。Dicyclomine hydrochloride是一种抗痉挛试剂，在体内可缓解胃肠道平滑肌痉挛。

靶点

Ki: 5.1 nM (muscarinic M1 receptor subtype in brush-border membrane)Ki: 54.6 nM (muscarinic M2 receptor subtype in basal plasma membrane

体内研究

Dicyclomine hydrochloride (intraperitoneal injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice.Dicyclomine hydrochloride (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks. Animal Model: C57Bl/6 mice Dosage: 2.0, 4.0, and 8.0 mg/kg Administration: Intraperitoneal injection; daily; 7 days Result: Produced impairments due to actions of the agent outside of the hippocampus.

Animal Model:

C57Bl/6 mice

Dosage:

2.0, 4.0, and 8.0 mg/kg

Administration:

Intraperitoneal injection; daily; 7 days

Result:

Produced impairments due to actions of the agent outside of the hippocampus.

类别

有毒物品

毒性分级

中毒

急性毒性

口服-大鼠 LD50: 625 毫克/公斤; 口服-小鼠 LD50: 625 毫克/公斤

可燃性危险特性

可燃;燃烧产生有毒氮氧化物和氯化氢烟雾;病人用药副作用;僵硬,呼吸困难,苍白

储运特性

通风低温干燥

灭火剂

干粉,泡沫,沙土,二氧化碳, 雾状水

危险品标志 

Xn

危险类别码 

22-36/37/38

安全说明 

26-36

WGK Germany 

3

RTECS号

DT7350000

海关编码 

2922199695

毒性

LD50 orl-rat: 1290 mg/kg DRUGAY 6,317,82