丁酸氯倍他松

中文名称:

丁酸氯倍他松

中文同义词:

丁酸倍氯他松;丁酸氯倍他松;氯倍他松丁酸酯;氯倍他松丁酸酯溶液,100PPM;丁酸氯倍他索;丁酸氯倍他松松;氯倍他松(氯倍氟松);氯倍他松丁酸盐

英文名称:

Clobetasone butyrate

英文同义词:

)-pregn-5-en-20-one;3,17-Dihydroxy-16-methyl-(3beta;)-3,17-Dihydroxy-2-(1-piperidinyl)androstan-16-yl]-1-methyl|piperidinium Bromide;)-16-Methyl-17,20:20,21-bis[methylenebis(oxy)]-pregna-1,4-diene-3,11-dione;)-3-(Acetyloxy)-17-hydroxy-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium Bromide-d3;-Hydroxytestosterone;)-11-Hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione;)-17-Acetyloxy-3-hydroxy-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium Bromide

CAS号:

25122-57-0

分子式:

C26H32ClFO5

分子量:

478.98

EINECS号:

246-635-9

相关类别:

医药原料药-科研原料;甾体激素 (激素，糖皮激素);甾体激素类;医药原料;化合物;原料药;Intermediates Fine Chemicals;Pharmaceuticals;Organics;Steroids

Mol文件:

25122-57-0.mol

熔点 

90-100°

沸点 

573.3±50.0 °C(Predicted)

密度 

1.1736 (estimate)

溶解度 

Practically insoluble in water, freely soluble in acetone and in methylene chloride, slightly soluble in ethanol (96 per cent).

形态

neat

稳定性

Stable. Combustible. Incompatible with strong oxidizing agents.

CAS 数据库

25122-57-0(CAS DataBase Reference)

用途

丁酸氯倍他松是一种外用糖皮质激素药，具有较强的毛细血管收缩作用，临床上主要用于治疗皮肤病。

生物活性

Clobetasone butyrate是一种新型的皮质类固醇，经常用于治疗湿疹、牛皮癣、皮肤炎和某些眼科疾病。

靶点

IC50: glucocorticoid

体内研究

Clobetasone butyrate (application on the skin; 0.05%; 7 weeks) induces epidermal thinning in skin, Clobetasone butyrate 7 weeks causes much less epidermal thinning in the pig than flurandrenolone (0.05%) or fluocinolone acetonide (0.025%), both of which causes severe atrophy. Animal Model: Large white domestic pig Dosage: 0.5% application on the skin Administration: 7 weeks Result: Caused moderate to slight atrophy.

Animal Model:

Large white domestic pig

Dosage:

0.5% application on the skin

Administration:

7 weeks

Result:

Caused moderate to slight atrophy.

危险品标志 

Xn

危险类别码 

40

安全说明 

22-36

WGK Germany 

3

RTECS号

TU4154083

海关编码 

29372290