中文同义词:
N-乙酰-5-羟色胺;N-乙酰羟色胺;N-乙酰基血清素;N-乙酰基-5-羟基色胺;N-乙酰-5-羟基色胺;N-乙酰-5-羟基色胺;羟色胺杂质5;N-(2-(5-羟基-1H-吲哚-3-基)乙基)乙酰胺
英文名称:
N-ACETYL-5-HYDROXYTRYPTAMINE
英文同义词:
N-Acetyl-5-hydroxytryptamine, 3-(N-Acetyl-2-aminoethyl)-5-hydroxyindole, 98%;N-Acetyl-5-hydroxytryptamine,N-Acetylserotonin, Normelatonin;3-(2-Acetamidoethyl)-5-hydroxyindole N-Acetylserotonin;N-Acetylserotonin, Normelatonin;Acetylserotonin;N-Acetyl-5-HT;N-Acetyl-5-hydroxy-1H-indole-3-ethaneamine;N-Acetyl-5-hydroxytryptamine,99%
相关类别:
化学试剂;试剂和补充物;小分子抑制剂;对照品;其他生化试剂;杂环化合物;药物杂质及中间体;Various Metabolites and Impurities;Tryptamines;Amino Acids;Heterocyclic Compounds;Indoles;Intermediates Fine Chemicals;Metabolites Impurities;Pharmaceuticals;Metabolites Impurities, Pharmaceuticals, Intermediates Fine Chemicals
沸点
556.8±40.0 °C(Predicted)
密度
1.268±0.06 g/cm3(Predicted)
酸度系数(pKa)
10.09±0.40(Predicted)
CAS 数据库
1210-83-9(CAS DataBase Reference)
生物活性
N-Acetyl-5-hydroxytryptamine (NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin) 是褪黑激素的前体,也是一种有效的 TrkB receptor 的选择性激动剂。
靶点
Target Value
TrkB receptor
()
体外研究
N-Acetyl-5-hydroxytryptamine (NAS), a precursor of Melatonin, is acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase). N-acetylserotonin activates TrkB receptor in a circadian rhythm. N-Acetyl-5-hydroxytryptamine swiftly activates TrkB in a circadian manner and exhibits antidepressant effect in a TrkB-dependent manner. N-Acetyl-5-hydroxytryptamine rapidly activates TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner.
体内研究
To explore whether N-Acetyl-5-hydroxytryptamine, can trigger TrkB activation in vivo, TrkB F616A knockin mice are employed, where it has been shown that TrkB F616A activation can be selectively blocked by 1NMPP1, a derivative of kinase inhibitor PP1, leading to TrkB-null phenotypes. To assess whether N-Acetyl-5-hydroxytryptamine can mimic BDNF, cortical neurons from TrkB F616A knockin mice are prepared. In alignment with a previous report, BDNF- and NAS-mediated TrkB phosphorylation are selectively reduced by 1NMPP1 but not by K252a, whereas serotonin or Melatonin had no effect . These findings suggest that NAS strongly provokes both wild-type TrkB and TrkB F616A tyrosine phosphorylation and activation.