羟丙基-BETA-环糊精
中文名称:
羟丙基-BETA-环糊精
中文同义词:
(2-羟丙基)-B-环糊精;羟丙基-Β-环糊精/羟丙基倍他环糊精/2-羟丙基-Β-环糊精;CAS号:128446-35-5或94035-02-6;羟丙基-BETA-环糊精/HPBCD;羟丙基-BETA-环糊精(右旋);2-羟丙基-Β-环糊精,97%;HYDROXYPROPYL-BETA-CYCLODEXTRIN 羟丙基-Β-环糊精;(2-羟丙基)-Β-环糊精 溶液
英文名称:
2-Hydroxypropyl-β-cyclodextrin
英文同义词:
beta-cyclodextrin,2-hydroxypropylether;(2-Hydroxypropyl)-^b-cyclodextrin, avge. MW ca 1340;(2-Hydroxypropyl)-^b-cyclodextrin, avge. MW ca 1400;Hydroxypropyl-beta-cyclodextrin,97%;(2-Hydroxypropyl)-beta-cyclode;(2-Hydroxypropyl)-beta-cyclodextrin, avge. MW ca 1400;(2-Hydroxypropyl)-beta-cyclodextrin, MW ca 1250-1480;(2-Hydroxypropyl)-β-cyclodextrin ,97%
CAS号:
128446-35-5
分子式:
C63H112O42
分子量:
1541.54
EINECS号:
420-920-1
相关类别:
碳水化合物类;医药原料;增溶剂和赋形剂;药用辅料;螯合;络合化合物;医药 增溶剂和赋形剂;多聚物及高分子有机物;食品添加剂;氨基酸;原料药;合成试剂;螯合/络合化合物;中间体;生化试剂;推荐环糊精-羟丙基倍他环糊精;生化试剂-碳水化合物类;香精香料;化工原料;其他原料;原料;Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Chelation/Complexation Compounds;Synthetic Reagents;CyclodextrinsCell Culture;CyclodextrinsSynthetic Reagents;Cell Signaling and Neuroscience;Lipids and Lipid Carriers;Reagents and Supplements;Signal Transduction Research Tools;Carbohydrates Derivatives;Other APIs;生化试剂-蛋白质;医用原料;化妆品原料;有机化工原料
Mol文件:
128446-35-5.mol
熔点
278 °C (dec.)
折射率
125 ° (C=1, H2O)
储存条件
room temp
溶解度
H2O: 45 % (w/v)
形态
solution (clear, colorless)
颜色
White to slightly yellow
旋光性 (optical activity)
[α]26/D +139°, c = 1 in H2O
水溶解性
Soluble in water.
InChIKey
ODLHGICHYURWBS-FOSILIAISA-N
EPA化学物质信息
.beta.-Cyclodextrin, 2-hydroxypropyl ethers (128446-35-5)
概述
羟丙基-BETA-环糊精是目前研究最为深入，应用最广泛的环糊精衍生物之一。其主要应用于食品、医药、化妆品行业。
用途
羟丙基-β-环糊精(HBC)是一种应用广泛的改性环糊精，由7个葡萄糖单位形成亲脂腔。药物与羟丙基-β-环糊精络合后，水溶性会大大增强。2-羟丙基的数目在5到14之间。
应用
羟丙基-BETA-环糊精是一种理想的注射剂增溶剂和药物赋形剂，可以提高难溶性药物的水溶性，增加药物稳定性、提高药物生物利用度，使药剂的疗效增加或服用量减少，可以调整或控制药物的释放速度，降低药物毒副作用。
1、在食品、香料领域，可提高营养分子的稳定性和长效性，可掩盖或矫正食品营养分子的不良气味和口味，可改进生产工艺和产品品质。该产品在水中的溶解度很好，取代度4及以上可以和水任意比例混溶，在50%的乙醇和甲醇中也能溶解。
2、在化妆品原料中用作稳定剂、乳化剂、去味剂等，可降低化妆品中有机分子对皮肤粘膜组织的刺激，增强有效成分的稳定性，防止营养成分的挥发、氧化。它有一定的相对吸湿性。
3、在医药工业中，由于相对表面活性和溶血活性比较低且对肌肉没有刺激性，所以它是一种理想的注射剂增溶剂和药物赋形剂。
生物活性
(2-Hydroxypropyl)-β-cyclodextrin是广泛使用的药物递送载体，可提高稳定性和利用度。
靶点
Target Value
amyloid-β aggregation
()
Target
Value
amyloid-β aggregation
()
体外研究
Cell treatment with (2-Hydroxypropyl)-β-cyclodextrin results in the activation of the transcription factor EB, a master regulator of lysosomal function and autophagy, and in enhancement of the cellular autophagic clearance capacity. (2-Hydroxypropyl)-β-cyclodextrin treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC 50 values for (2-Hydroxypropyl)-β-cyclodextrin after 72 hours exposure are in the range of 3.86–10.09 mM. (2-Hydroxypropyl)-β-cyclodextrin also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by (2-Hydroxypropyl)-β-cyclodextrin.
体内研究
(2-Hydroxypropyl)-β-cyclodextrin administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system in cells derived from a patient with a lysosomal storage disorder. Intraperitoneal injection of (2-Hydroxypropyl)-β-cyclodextrin significantly improves survival in leukemia mouse models. Systemic administration of (2-Hydroxypropyl)-β-cyclodextrin to mice has no significant adverse effects.
安全说明
24/25
WGK Germany
3
RTECS号
GU2293332
TSCA
Yes
海关编码
29400090
