头孢噻肟酸
中文名称:
头孢噻肟酸
中文同义词:
头孢氨噻溶液,100PPM;孢氨噻;头孢氨噻;头孢氨噻肟;头孢噻肟;头孢噻肟酸;头孢噻肟杂质;噻胞霉素
英文名称:
Cefotaxime
英文同义词:
Cefotaxime;Cefotaxima acid;(6R,7R)-3-[(Acetyl-oxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-;Cefabol;Cephotaxime;(((2-amino- 4-thiazolyl)methoxyimino)acetyl)amino)-8-oxo-, (6r-(6alpha,7beta(z) 3-[(Acetyloxy)methyl]-7-[[(2-amino-4-thiazoly)(methoxyimino)acethyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid(sodium salt);(6R)-3-(Acetoxymethyl)-7α-[[(2-amino-4-thiazolyl)[(Z)-methoxyimino]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS号:
63527-52-6
分子式:
C16H17N5O7S2
分子量:
455.47
EINECS号:
264-299-1
相关类别:
医药标准品;杂质对照品;中间体;医药化工类;原料中间体-原料药;对照品-杂质对照品;医药原料;Pharmaceutical intermediate;原料;原料药;化工中间体工业原料;医药、农药及染料中间体;杂质对照品;陕西林奈主打产品
Mol文件:
63527-52-6.mol
密度
1.80±0.1 g/cm3(Predicted)
形态
neat
酸度系数(pKa)
pKa 2.1 (H2O t=20.0 I<0.005 ) (Uncertain);3.4(H2O t=20.0 I<0.005 ) (Uncertain);10.9(H2O t=20.0 I<0.005 ) (Uncertain)
CAS 数据库
63527-52-6(CAS DataBase Reference)
EPA化学物质信息
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)- (63527-52-6)
生物活性
Cefotaxime是第三代头孢菌素抗生素，对革兰氏阴性菌和阳性菌具有广谱活性。
体外研究
Cefotaxime exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6.
体内研究
The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus in vivo than previously used regimens.
Animal Model: Female, specific pathogen free, 8-week-old BALB/c mice.
Dosage: 30 mg/kg.
Administration: IP every 6 h.
Result: The viable bacterial counts in liver were lower in mice treated with cefotaxime-plus-ciprofloxacin than in those treated with cefotaxime alone (P<0.001 at 24 h and 48 h, each).
Animal Model:
Female, specific pathogen free, 8-week-old BALB/c mice.
Dosage:
30 mg/kg.
Administration:
IP every 6 h.
Result:
The viable bacterial counts in liver were lower in mice treated with cefotaxime-plus-ciprofloxacin than in those treated with cefotaxime alone (P<0.001 at 24 h and 48 h, each).
化学性质
白色粉末。熔点162-163℃（分解）。易溶于水。稀溶液无色或微黄色，浓度较高时呈灰黄色。变质时呈深黄色或棕色。
用途
半合成肟型头孢菌素，为第三代头孢菌素。本品对革兰阴性菌、尤其对肠杆菌作用强大。主要用于敏感菌所致呼吸系统感染，泌尿系统感染，胆道及肠道感染，皮肤及软组织感染，烧伤和骨关节感染等。
用途
用作抗菌药，属半合成肟型头孢菌素
生产方法
以发酵生产的头孢菌素C为原料，经裂解得7-氨基头孢烷酸（7-ACA），再经硅酯化，与侧链酸缩合、水解、结晶得头孢噻肟，再与醋酸钠成盐，经脱色、无菌过滤、结晶得到头孢噻肟（钠盐）成品。
RTECS号
XI0240000
海关编码
29419000
