昔美酸沙美特罗
中文名称:
昔美酸沙美特罗
中文同义词:
苯磺阿曲库铵;葛兰素威;昔美酸沙美特罗;甲醇中沙米特罗溶液标准物质;沙美特罗羟萘甲酸盐:昔美酸沙美特罗;沙美特罗羟萘甲酸盐/2-羟甲基-4-[1-羟基-2-[6-(4-苯基丁氧基)己基氨基]乙基]苯酚 1-羟基-2-萘甲酸盐;2-羟甲基-4-[1-羟基-2-[6-(4-苯基丁氧基)己基氨基]乙基]苯酚 1-羟基-2-萘甲酸盐;沙美特罗羟萘甲酸盐
英文名称:
Salmeterol xinafoate
英文同义词:
(+/-) 4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]M-ETHYL]-1,3-BENZENEDIMETHANOL XINAFOATE;GR 33343X XINAFOATE;Arial;GR-33343G;Salmetedur;Salmeterol, 1-Hydroxy-2-naphthoate;Serevent;1,3-Benzenedimethanol, 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-, (+-)-, 1-hydroxy-2-naphthalenecarboxylate (salt)
CAS号:
94749-08-3
分子式:
C36H45NO7
分子量:
603.74
EINECS号:
相关类别:
分析标准品;其他科研原料药;小分子抑制剂，天然产物;医药原料;医药原料药;平喘药;原料药;Active Pharmaceutical Ingredients;API;Intermediates Fine Chemicals;Pharmaceuticals;Adrenoceptor;Amines;Aromatics;Stable Isotopes;Inhibitors;中药对照品;标准品;原料;陕西林奈主打产品
Mol文件:
94749-08-3.mol
熔点
137-138°C
储存条件
2-8°C
溶解度
H2O: slightly soluble
形态
solid
颜色
white
Merck
14,8337
InChIKey
XTZNCVSCVHTPAI-UHFFFAOYSA-N
CAS 数据库
94749-08-3(CAS DataBase Reference)
生物活性
Salmeterol Xinafoate是一种长效的β2-adrenergic receptor激动剂，具有抗炎作用，用于哮喘症状和慢性阻塞性肺疾病（COPD）症状的治疗。
靶点
Target Value
β2-adrenergic receptor
Target
Value
β2-adrenergic receptor
体外研究
Salmeterol (0.001-25 µM) inhibits human T lymphocyte proliferation.
Cell Proliferation Assay
Cell Line: Human T lymphocytes (THP-1 cells)
Concentration: 0.001, 0.01, 0.05, 0.2, 1, 5, and 25 µM
Incubation Time:
Result: The proliferation of Th2 cells was inhibited in a concentration dependent manner.
Cell Line:
Human T lymphocytes (THP-1 cells)
Concentration:
0.001, 0.01, 0.05, 0.2, 1, 5, and 25 µM
Incubation Time:
Result:
The proliferation of Th2 cells was inhibited in a concentration dependent manner.
体内研究
Salmeterol (0.16 mg/kg), Formoterol (0.32 mg/kg) and combined treatment have therapeutic effects in mice with chronic obstructive pulmonary disease (COPD).
Animal Model: Male C57BL/6 mice (6-8 weeks old, body weight: 32-35 g)
Dosage: Salmeterol (0.16 mg/kg) and/or Formoterol (0.32 mg/kg)
Administration: The therapeutic efficacy of co-treatment was investigated in this model over a 56-day-long observation period.
Result: COPD assessment test scores were markedly improved in mice with COPD.
Animal Model:
Male C57BL/6 mice (6-8 weeks old, body weight: 32-35 g)
Dosage:
Salmeterol (0.16 mg/kg) and/or Formoterol (0.32 mg/kg)
Administration:
The therapeutic efficacy of co-treatment was investigated in this model over a 56-day-long observation period.
Result:
COPD assessment test scores were markedly improved in mice with COPD.
用途
用于治疗哮喘和慢性、梗阻性肺病
用途
用于哮喘的长期治疗和支气管痉挛、可逆性气道阻塞的预防
危险品标志
Xi
危险类别码
36/37/38
安全说明
22-24/25-36-26
WGK Germany
3
RTECS号
QJ1970500
海关编码
2922504500
