补骨脂定

中文名称:

补骨脂定

中文同义词:

补骨脂定, BR;补骨酯定;补骨脂定(标准品);PSORALIDIN 补骨脂定标准品;补骨脂定;PSORALIDIN 补骨脂定;补骨脂啶;补骨脂定对照品

英文名称:

psoralidin

英文同义词:

3,9-Dihydroxy-2-prenylcoumestan;Psoralidin, >=99%;psoralidin;3,9-Dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro[3,2-c][1]benzopyran-6-one;Psorslidin;Psoralidin, BR;6H-Benzofuro[3,2-c][1]benzopyran-6-one, 3,9-dihydroxy-2-(3-methyl-2-buten-1-yl)-;3,9-Dihydroxy-2-(3-methylbut-2-en-1-yl)-6H-benzofuro[3,2-c]chromen-6-one

CAS号:

18642-23-4

分子式:

C20H16O5

分子量:

336.34

EINECS号:

相关类别:

补骨脂系列;植物提取物;对照品;植提标准品;中药对照品;标准品;对照品,标准品;标准品-对照品;对照品-中药对照品;木脂素;标准品 -中药标准品;分析试剂-对照品;标准品，对照品

Mol文件:

18642-23-4.mol

熔点

290-292°

沸点

458.8±34.0 °C(Predicted)

密度

1.383±0.06 g/cm3(Predicted)

储存条件

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: soluble5mg/mL, clear (warmed)

酸度系数(pKa)

8.70±0.20(Predicted)

形态

powder

颜色

white to beige

InChIKey

YABIJLLNNFURIJ-UHFFFAOYSA-N

生物活性

Psoralidin 是从 Psoralea corylifolia 的种子中分离出来的，是 COX-2 和 5-LOX 的双重抑制剂。具有抗癌，抗菌和抗炎作用。Psoralidin 显著下调 NOTCH1 信号传导。Psoralidin 还极大地诱导 ROS 产生。

靶点

COX-2 5-LOX

COX-2

5-LOX

体外研究

Three breast cancer cell (BCC)populations (ALDH - cells, ALDH + cells, and commercial BSCSs) are sensitive to Psoralidin treatment (10, 15, 20, and 25 μM; 24 hours) with IC 50 s ranging from 18 to 21 μM; however, the MCF-12A cells were resistant to Psoralidin. Psoralidin (30 μM; 24 hours) results in a significant induction of apoptosis for ALDH - cells, ALDH + cells, and commercial BCSCs. Psoralidin treatment also downregulates NOTCH1 expression in both ALDH - and ALDH + cells. Cell Viability Assay Cell Line: ALDH - cells, ALDH + cells, commercial breast cancer stem cells (BSCSs), and normal breast epithelial cells (MCF-12A) Concentration: 10, 15, 50, and 25 μM Incubation Time: 24 hours Result: IC 50 s of 18 to 21 μM for ALDH - cells, ALDH + cells, commercial BCSCs. Apoptosis Analysis Cell Line: ALDH - cells, ALDH + cells, and commercial BCSCs Concentration: 20 and 30 μM Incubation Time: 24 hours Result: No significant induction of apoptosis was observed for any of the three cell types following treatment at 20 μM. However, 53.60%, 44.1%, and 45.9% of cells were apoptotic at 30 μMin ALDH - cells, ALDH + cells, and commercial BCSCs, respectively.

Cell Line:

ALDH - cells, ALDH + cells, commercial breast cancer stem cells (BSCSs), and normal breast epithelial cells (MCF-12A)

Concentration:

10, 15, 50, and 25 μM

Incubation Time:

24 hours

Result:

IC 50 s of 18 to 21 μM for ALDH - cells, ALDH + cells, commercial BCSCs.

Cell Line:

ALDH - cells, ALDH + cells, and commercial BCSCs

Concentration:

20 and 30 μM

Incubation Time:

24 hours

Result:

No significant induction of apoptosis was observed for any of the three cell types following treatment at 20 μM. However, 53.60%, 44.1%, and 45.9% of cells were apoptotic at 30 μMin ALDH - cells, ALDH + cells, and commercial BCSCs, respectively.

体内研究

Psoralidin (5 mg/kg) regulates expression of pro-inflammatory cytokines that play an important role in inflammatory diseasesin IR-irradiated lung of BALB/c mouse. Animal Model: BALB/c mice Dosage: 5 mg/kg Administration: Intraperitoneal application; 30 min before and 1 h after IR irradiation (20 Gy). Result: Anti-inflammatory effect in IR-irradiated mice.

Animal Model:

BALB/c mice

Dosage:

5 mg/kg

Administration:

Intraperitoneal application; 30 min before and 1 h after IR irradiation (20 Gy).

Result:

Anti-inflammatory effect in IR-irradiated mice.

化学性质

淡黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于补骨脂Psoralea corylifolia Linn.种子。

用途

补骨脂定具有抗真菌，细胞毒，扩张冠状动脉、止血的作用。