人参皂甙 Rh2

中文名称:

人参皂甙 Rh2

中文同义词:

人参皂苷 S-RH2;人参皂苷RH2(标准品);人参皂荚RH2;人参皂甙 Rh2;(R型)人参皂苷RH2;人参皂苷-RH2;人参皂苷RH2(R);(S型)人参皂苷RH2(标准品)

英文名称:

Ginsenoside Rh2

英文同义词:

b-D-Glucopyranoside, (3b,12b)-12,20-dihydroxydaMMar-24-en-3-yl;(3β,12β)-12,20-Dihydroxydammar-24-en-3-yl-β-D-glucopyranoside;Ginsenoside Rh2, 20(S)-;(3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-d-glucopyranoside;GINSENOSIDE RH2;dihydroxydammar-24-en-3-yl;β-D-Glucopyranoside, (3β,12β)-12,20-;R-form-Ginsenoside Rh2

CAS号:

78214-33-2

分子式:

C36H62O8

分子量:

622.88

EINECS号:

相关类别:

医药中间体;植提标准品;小分子抑制剂，天然产物;中药标准品;天然产物;中药对照品;标准品;生化试剂;对照品,标准品;癌症研究;植物提取物;对照品;小分子抑制剂;化学试剂;生化试剂-其他化学试剂;标准品-中药标准品;标准品，对照品;对照品-中药对照品;标准品 -中药标准品;三萜;分析试剂-对照品;Ginsenoside series;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;含量产品

Mol文件:

78214-33-2.mol

熔点

139-144 °C

沸点

726.4±60.0 °C(Predicted)

密度

1.19±0.1 g/cm3(Predicted)

储存条件

Inert atmosphere,2-8°C

酸度系数(pKa)

12.91±0.70(Predicted)

形态

neat

InChIKey

CKUVNOCSBYYHIS-IRFFNABBSA-N

CAS 数据库

78214-33-2(CAS DataBase Reference)

概述

人参皂苷Rh2是从人参中提炼出来的抗癌活性植物成分，目前已被已被越来越多的肿瘤患者所认可，改善病人生活质量、延长生命具有很好的效果，故享有了“护命素”的美誉。护命素具体表现为辅助治疗各类癌症，化学名为原人参二醇-3-氧-B-D-吡喃葡萄糖苷，即人参皂苷Rh2。

生物活性

Ginsenoside Rh2 是从 Ginseng 根中分离出来的。Ginsenoside Rh2 诱导 caspase-8 和 caspase-9 活化。Ginsenoside Rh2 以多途径方式诱导癌细胞凋亡。

靶点

Caspase-8 Caspase-9 Human Endogenous Metabolite Apoptosis

Caspase-8

Caspase-9

体外研究

Ginsenoside Rh2 induces the activation of two initiator caspases, caspase-8 and caspase-9 in human cancer cells. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner and is therefore a promising candidate for anti-tumor drug development. Ginsenoside Rh2 triggers p53-dependent Fas expression and consequent activation of caspase-8 and p53-independent caspase-9-mediated intrinsic pathway to cause cancer cell death.The cytotoxic activity of Ginsenoside Rh2 in the human tumor cell lines HeLa, SK-HEP-1, SW480, and PC-3 is assessed by MTT. The cell viability of HeLa cells is remarkably inhibited by Ginsenoside Rh2, with an IC 50 value of 2.52 μg/mL, whereas SK-HEP-1 and SW480 cells are less sensitive to Ginsenoside Rh2, with IC 50 values of 3.15 μg/mL and 4.06 μg/mL, respectively. PC-3 cells are the least vulnerable to Ginsenoside Rh2, with an IC 50 value of 7.85 μg/mL, 3-fold higher than HeLa cells.

体内研究

A total of 15 days following B16-F10 cell injection, tumor sizes from the 3 tumor bearing groups are measured. The tumor sizes in the G-L group and G-H group (G-L and G-H refer to a low or high dose of ginsenoside Rh2 injection) are reduced compared with the tumor group (P<0.05). The survival analysis reveals that the Ginsenoside Rh2 treated groups survive longer than the untreated tumor group and the effect is dose-dependent (P<0.05).

化学性质

白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参。

用途

用于含量测定/鉴定/药理实验等。药理药效:1.在1.0mg/mL时，对于由CCl4诱导的大鼠肝中毒有显著的保护作用。2.抑制黑色素瘤B16细胞核人卵巢癌细胞的增生。3.对MT-4细胞有细胞毒活性。

用途

(20S)-人参皂苷Rh2是从人参中分离到的三萜皂苷，具有很高的抗炎、抗癌活性。

危险品标志

危险类别码

安全说明

24/25

WGK Germany

RTECS号