2,3-二巯基丁二酸
中文名称:
2,3-二巯基丁二酸
中文同义词:
间-2,3-二巯基丁二酸;内消旋-2,3-二巯基丁二酸,98%;内消旋-2,3-二巯基丁二酸(>98.0%(T));2,3-二硫代-内消旋酒石酸;二琉基丁二酸(2,3-二巯基丁二酸);2,3-二巯基丁二酸 5G;二锍丁二酸;MESO-2,3-二巯基丁二酸
英文名称:
Succimer
英文同义词:
(2R,3S)-2,3-diMercaptosuccinic acid;(2R,3S)-rel-2,3-DiMercaptosuccinic acid;Butanedioic acid,2,3-diMercapto-, (2R,3S)-rel-;meso-2,3-Dimercaptosuccinic acid;API Succimer;-rel-2,3-Dimercaptosuccinic acid;(2S,3R)-2,3-dimercaptobutanedioate;(r*,s*)-2,3-dimercaptobutanedioicacid
CAS号:
304-55-2
分子式:
C4H6O4S2
分子量:
182.22
EINECS号:
206-155-2
相关类别:
医药中间体;羰基化合物;有机砌块;标准品;有机化工原料;有机原料;医用原料;Organic acids;原料;小分子抑制剂;Inhibitors;小分子抑制剂，天然产物;医药原料;抗病毒抗感染类;原料药;API;硫醇类;巯基化合物;医药原料药;化工原料;产品;Analytical Chemistry;Ligands for Pharmaceutical Research;Radiopharmaceutical Chemistry (Chelating Reagents);Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;Thiols/Mercaptans
Mol文件:
304-55-2.mol
熔点
196-198 °C (dec.)(lit.)
沸点
285.62°C (rough estimate)
密度
1.439 (estimate)
折射率
1.5220 (estimate)
储存条件
-20°C
酸度系数(pKa)
pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C)
形态
Powder
颜色
White to off-white
水溶解性
Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear).
Merck
14,8865
BRN
1725150
稳定性
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
ACTRVOBWPAIOHC-XIXRPRMCSA-N
CAS 数据库
304-55-2(CAS DataBase Reference)
EPA化学物质信息
Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel- (304-55-2)
生物活性
Succimer (Dimercaptosuccinic acid) 是一种广泛用于研究铅中毒的螯合剂。
体内研究
Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.
化学性质
白色结晶性粉末。熔点196-198℃（分解）。易溶于碱溶液，微溶于甲醇，不溶于水。具有巯基化合物的特臭，在空气中逐渐氧化。
用途
该品是解毒药二巯基丁二酸钠的中间体。
用途
用作重金属解毒药、保健药
用途
一种镉的选择性掩蔽剂，用于锌的EDTA滴定
生产方法
由二溴丁二酸经消除、加成、水解而得。
危险品标志
Xi
危险类别码
36/37/38
安全说明
24/25-36-26
WGK Germany
2
RTECS号
WM7650000
F
10-23
TSCA
Yes
海关编码
29309090
毒害物质数据
304-55-2(Hazardous Substances Data)
毒性
LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi)
