中文同义词:
原苏木素A;原苏木素A标准品;原苏木素A对照品
英文同义词:
protosappanin A;Sappanol B;3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one;PROTOSAPPANIN A (PTA);6H-Dibenz[b,d]oxocin-7(8H)-one, 3,10,11-trihydroxy-
相关类别:
对照品，标准品，含量测定，药理研究;标准品-对照品;标准品，对照品;对照品;其它酚类;标准品，对照品
沸点
613.1±55.0 °C(Predicted)
密度
1.476±0.06 g/cm3(Predicted)
酸度系数(pKa)
9.01±0.20(Predicted)
生物活性
Protosappanin A (PTA)，是一种免疫制剂，是从 Caesalpinia sappan L 中分离得到的一种主要联苯化合物，通过下调 JAK2 和 STAT3 的磷酸化，抑制 JAK2/STAT3 依赖的炎症通路。
体外研究
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) significantly inhibits the production of TNF-α and IL-1β in LPS-activated BV2 microglia. And the mRNA expressions of IL-6, IL-1β, and MCP-1 are reduced by PTA in a dose-dependent manner in BV2 microglial cell line.
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3, as well as STAT3 nuclear translocation against LPS treatment.
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) shows obvious effect on disturbing the interaction of transmembrane protein CD14 with Toll-like receptor-4, resulting in the inhibition of NF-κB-dependent oxidative and nitrative stress in LPS-induced BV2 microglia.
Western Blot Analysis
Cell Line: Murine BV2 microglial cell line.
Concentration: 12.5, 25, 50 μM.
Incubation Time: 24 hours.
Result: Inhibits the releases of NO, TNF-α and IL-1β in LPS-induced BV2 cells.
Attenuated IL-6, IL-1β and MCP-1 gene expressions in the LPS-induced BV2 cells.
Suppressed JAK2/STAT3 pathway activation in the LPS-induced BV2 cells.
Cell Line:
Murine BV2 microglial cell line.
Concentration:
12.5, 25, 50 μM.
Incubation Time:
24 hours.
Result:
Inhibits the releases of NO, TNF-α and IL-1β in LPS-induced BV2 cells.
Attenuated IL-6, IL-1β and MCP-1 gene expressions in the LPS-induced BV2 cells.
Suppressed JAK2/STAT3 pathway activation in the LPS-induced BV2 cells.
