盐酸石蒜碱
中文名称:
盐酸石蒜碱
中文同义词:
石蕊碱;盐酸石蒜碱石蒜碱盐酸盐、水仙碱、异鼠李素-3-Β-D-芸香糖甙;水仙碱;异鼠李素-3-Β-D-芸香糖甙(水仙甙);石蒜碱;LYCORINE CHLORIDE 盐酸石蒜碱 标准品;盐酸石蒜碱;盐酸石蒜碱(石蒜碱盐酸盐,水仙碱)
英文名称:
Lycorine hydrochloride
英文同义词:
Lycorine Hydrochloride98%;Licorin hydrochloride;Hydrochloric Lycorine;LYCORIN;(-)-LYCORINE;LYCORINE;1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol,2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)-;NARCISSIN(P)
CAS号:
2188-68-3
分子式:
C16H17NO4
分子量:
287.31
EINECS号:
相关类别:
植物药;植提;中药标准品;分析试剂标准品;植提标准品;植物生化提取物;中药对照品;标准品;分析标准品;植物提取物;对照品;中间体;小分子抑制剂;小分子抑制剂，天然产物;植物成分单体;细胞生物学试剂;标准品-中药标准品;标准品 -中药标准品;Peptidyl transferaseCell Signaling and Neuroscience;Enzyme Inhibitors by Enzyme;Gene Regulation and Expression;P to;RNA-Protein Translation Inhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;分析试剂-标准品;标准品-对照品;其他原料
Mol文件:
2188-68-3.mol
熔点
206 °C
储存条件
2-8°C
形态
powder
生物活性
Lycorine hydrochloride 是石蒜的主要活性成分，也是黑色素瘤血管生成抑制剂，具有抗肿瘤活性。Lycorine hydrochloride 能有效抑制 Hey1B 细胞的有丝分裂增殖 (IC50 为 1.2 μM)。
靶点
IC50: 1.2 μM (Hey1B cells )
体外研究
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected.
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
RT-PCR
Cell Line: C8161 cells
Concentration: 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM
Incubation Time: 48 hours
Result: Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells.
Western Blot Analysis
Cell Line: C8161 cells
Concentration: 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM
Incubation Time: 48 hours
Result: Markedly reduced VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
Cell Line:
C8161 cells
Concentration:
0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM
Incubation Time:
48 hours
Result:
Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells.
Cell Line:
C8161 cells
Concentration:
0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM
Incubation Time:
48 hours
Result:
Markedly reduced VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
体内研究
Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
Animal Model: 6- to 8-week-old BALB/C nude mice
Dosage: 0 μg, 7.5 μg, 15 μg
Administration: Subcutaneous injection; for 14 days
Result: Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
Animal Model:
6- to 8-week-old BALB/C nude mice
Dosage:
0 μg, 7.5 μg, 15 μg
Administration:
Subcutaneous injection; for 14 days
Result:
Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
化学性质
白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于石蒜鳞茎。
用途
一种选择性的PTC抑制剂。
用途
肽转移酶中心（peptidyl transferase center ，PTC）的选择性抑制剂。
危险品标志
T
危险类别码
25
安全说明
45
危险品运输编号
UN 2811 6.1/PG 3
WGK Germany
3
