中文名称:

4,4-二甲氧基查耳酮

中文同义词:

4,4-二甲氧基查耳酮;4,4-二甲氧基查耳酮,99%;4,4-甲氧基查耳酮

英文名称:

4,4-DIMETHOXYCHALCONE

英文同义词:

1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE;2-Propen-1-one, 1,3-bis(4-methoxyphenyl)-;Ai3-25492;Nsc 87339;4,4-DIMETHOXYCHALCONE;4,4-DIMETHOXYBENZYLIDENEACETOPHENONE;DIMETHOXYCHALCONE,4,4-;(E)-1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE

CAS号:

2373-89-9

分子式:

C17H16O3

分子量:

268.31

EINECS号:

相关类别:

植物提取物;标准品;Chalcones

Mol文件:

2373-89-9.mol

熔点 

101°C

沸点 

444.6±45.0 °C(Predicted)

密度 

1.128±0.06 g/cm3(Predicted)

BRN 

1622293

CAS 数据库

2373-89-9(CAS DataBase Reference)

生物活性

4,4-Dimethoxychalcone 可从植物当归中分离得到，是一种天然自噬 (autophagy) 诱导剂，具有抗衰老活性。

靶点

Autophagy

体内研究

The flavonoid 4,4-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species. 4,4-Dimethoxychalcone (100 mg/kg; intraperitoneally) efficiently triggered autophagic flux in the heart and liver from wild type (WT) C57BL/6 mice. Animal Model: 6-week-old male wild type C57BL/6 or Atg4b -/- mice Dosage: 100 mg/kg Administration: Injected intraperitoneally with a single Result: Triggered autophagic flux in the heart and liver.

Animal Model:

6-week-old male wild type C57BL/6 or Atg4b -/- mice

Dosage:

100 mg/kg

Administration:

Injected intraperitoneally with a single

Result:

Triggered autophagic flux in the heart and liver.

海关编码 

29145090