中文同义词:
(S)-alpha-甲基-alpha-肼基-3,4-二羟基苯丙酸一水合物;卡比多巴;(S)-(-)-多巴一水;卡比多巴单水合物;(S)-3-(3,4-二羟基苯基)-2-肼基-2-甲基丙酸水合物;卡比多巴一水合物;卡比多巴,一水;卡比多巴(CEP EU GMP DMF)
英文名称:
Carbidopa Monohydrate
英文同义词:
(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic Acid;Carbidopa SynonyMs (+)-2-(3,4-Dihydroxybenzyl)-2-hydrazinopropionic acid Monohydrate;(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid monohydrate;Carbidopa for system suitability;Carbidopa(CEP/FDA);CARBIDOPA;CARBIDOPA HYDRATE;CARBIDOPA MONOHYDRATE
相关类别:
有机中间体;标准品;科研用原料药;现货;医药原料;药物成分 (研究实验用);Other APIs;Pharmaceutical intermediates;小分子抑制剂;Inhibitors;小分子抑制剂，天然产物;原料药;医用原料;原料;中药对照品;有机中间体
溶解度
Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids.
CAS 数据库
38821-49-7(CAS DataBase Reference)
用途
卡比多巴为类白色绒毛状结晶；几乎无臭。与左旋多巴联合应用，用于帕金森病和帕金森综合征。
生物活性
Carbidopa ((S)-(-)-Carbidopa) monohydrate 是一种外周型脱羧酶 (decarboxylase) 抑制剂，可用于帕金森病的研究。Carbidopa monohydrate 是一种选择性芳香烃受体 (AhR) 调节剂。Carbidopa monohydrate 抑制胰腺癌细胞和肿瘤生长。
体外研究
Carbidopa ((S)-(-)-Carbidopa) monohydrate exhibits activities similar to that described for other AhR ligands in BχPC3 and Capan-2 cells, namely the induction of CYP1A1 and CYP1A2, which are inhibited by AhR antagonists such as CH223191.
Carbidopa, a aromatic-L-amino acid decarboxylase inhibitor, is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Carbidopa is lethal (IC 50 =29 μM).
体内研究
Carbidopa monohydrate also induces nuclear uptake of the AhR, and in vivo studies show that carbidopa at a dose of 1 mg/mouse significantly inhibits tumor growth in athymic nude mice bearing BχPC3 cells as xenografts.
急性毒性
口服-大鼠 LD50: 4810 毫克/公斤; 口服-小鼠 LD50: 1750 毫克/公斤
