中文名称:

盐酸地托咪定

中文同义词:

盐酸地拖咪啶;4-[(2,3-二甲基苯基)甲基]-1H-咪唑盐酸盐;盐酸地托咪定;盐酸地托咪啶;盐酸地拖嘧啶;地托咪定盐酸盐;地托咪啶;地托米定盐酸盐

英文名称:

Detomidine hydrochloride

英文同义词:

5-(2,3-Dimethylbenzyl)imidazole Hydrochloride;5-[(2,3-DiMethylphenyl)Methyl]-1H-iMidazole Hydrochloride;DoMosedan;DorMosedan;MPV 253AII;DetoMidine hydrochloride (DorMosedan);API017;DTMT.HCl

CAS号:

90038-01-0

分子式:

C12H15ClN2

分子量:

222.7139

EINECS号:

相关类别:

神经信号;小分子抑制剂，天然产物;医药原料药;定制化学品;原料药;医用原料;APIs;API;Aromatics;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals;Inhibitors;标准品;医药原料;杂质对照品;化学试剂

Mol文件:

90038-01-0.mol

熔点 

160°C

形态

neat

InChIKey

OIWRDXKNDCJZSM-UHFFFAOYSA-N

生物活性

Detomidine HCl可产生镇静和镇痛作用，这种作用具有剂量依赖性，通过激活α2儿茶酚胺受体来调节。

靶点

Target Value Adrenergic Receptor

Target

Value

Adrenergic Receptor

体外研究

Currently, detomidine is only licenced for use in horses. Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action.

危险品运输编号 

UN 2811 6.1 / PGIII

RTECS号

NI5160000