中文名称:

盐酸妥布特罗

中文同义词:

盐酸妥布托罗;盐酸妥布特;妥布特罗甲醇溶液标准物质;妥洛特罗盐酸;妥布特罗盐酸盐溶液,100PPM;2-叔丁氨基-1-(2-氯苯基)乙醇 盐酸盐;甲醇中妥布特罗溶液标准物质;妥布特罗盐酸盐

英文名称:

Tulobuterol hydrochloride

英文同义词:

Ventaire;Tulobuterol hydrochloride API;Tulobuterol solution;Tulobuterol Hydrochloride Solution, 100ppm;TULOBUTEROL HCl 99%;TULOBUTEROL HG;Atenos;Benzenemethanol, 2-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-, hydrochloride (9CI)

CAS号:

56776-01-3

分子式:

C12H19Cl2NO

分子量:

264.19

EINECS号:

634-677-4

相关类别:

平喘药;平喘药原料药;法医和兽医标准品;抗生素;瘦肉精类;分析标准品;医药原料药-科研原料;医药原料;医药原料;标准品;中药对照品;Active Pharmaceutical Ingredients;API;医药原料药;原料药;原料

Mol文件:

56776-01-3.mol

熔点 

159-163℃

储存条件 

2-8°C

形态

neat

水溶解性 

Soluble in methanol or water.

敏感性 

Hygroscopic

Merck 

14,9811

InChIKey

RSLNRVYIRDVHLY-UHFFFAOYSA-N

CAS 数据库

56776-01-3(CAS DataBase Reference)

生物活性

Tulobuterol是长效的β2-adrenergic receptor激动剂，具有支气管扩张、消炎和抗病毒活性。

靶点

β2-adrenoceptor

体外研究

Tulobuterol (0.1 μM; 24 hours or 72 hours; human tracheal epithelial cells) treatment decreases the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells treated with tulobutero are significantly lower than those in the cells treated with vehicle before RV14 infection. Treatment with tulobuterol reduces the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduces the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. Tulobuterol treatment produces a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection. RT-PCR Cell Line: Human tracheal epithelial cells infected with RV14 Concentration: 0.1 μM Incubation Time: 24 hours or 72 hours Result: Decreased the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells were significantly lower. Reduced the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduced the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. And produced a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.

Cell Line:

Human tracheal epithelial cells infected with RV14

Concentration:

0.1 μM

Incubation Time:

24 hours or 72 hours

Result:

Decreased the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells were significantly lower. Reduced the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduced the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. And produced a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.

体内研究

In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice; 21.7 ± 0.2 g) treated with Endotoxin. Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E. coli endotoxin (20 mg/kg) administration are measured. E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of endotoxin administration with Tulobuterol patch for over 24 h.

类别

有毒物质

毒性分级

高毒

急性毒性

口服-大鼠 LD50: 560 毫克/公斤; 口服-小鼠 LD50: 243 毫克/公斤

可燃性危险特性

热分解排出有毒氮氧化物, 氯化物气体

储运特性

库房通风低温干燥; 与食品原料类分开存放

灭火剂

水,干粉、干砂、二氧化碳、泡沫、1211灭火剂

危险品标志 

Xn

危险类别码 

22

WGK Germany 

3

RTECS号

DN8785000