中文同义词:
双醋酚丁;双醋酚丁 标准品;双醋酚丁衍生物;双丙酚丁;双丙富马酸盐
英文名称:
oxyphenisatine di(acetate)
英文同义词:
oxyphenisatine di(acetate);OXYPHENISATIN ACETATE;Isapheninum;Isaphenin;3,3-Bis[4-(acetyloxy)phenyl]-1,3-dihydro-2H-indol-2-one;Isocrin;Levema;NSC-59687
沸点
566.5±50.0 °C(Predicted)
密度
1.282±0.06 g/cm3(Predicted)
酸度系数(pKa)
13.55±0.40(Predicted)
用途
双醋酚丁是一种化学物质，临床药品口服后在肠内遇碱性肠液逐渐分解成醋酸和酚丁，酚丁对肠粘膜的刺激作用比酚肽强数十倍，故其导泻作用较强。
生物活性
Oxyphenisatin acetate是oxyphenisatin的前体药物，过去常用作泻药。
体外研究
Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction.
体内研究
Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model.
毒性
LD50 oral in rat: 1900mg/kg
