中文同义词:
BENZIMIDAVIR 苯并咪唑核苷;苯并咪唑核苷;马立巴韦
英文同义词:
Maribavi;5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(BETA-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE;BENZIMIDAVIR;BENZIMIDAVIR, 5,6-DICHLORO-2-（ISOPROPYLAMINO）-1-(β-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE;5,6-DICHLORO-2-ISOPROPYLAMINO-1-(-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE;BENZIMIDAVIR: 5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(SS-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE;(2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]-imidazol-1-yl)-5-(hydroxymethyl)tetr;Maribavir
相关类别:
小分子抑制剂;小分子抑制剂，天然产物;成熟工艺;化工原料;Inhibitors
沸点
611.0±65.0 °C(Predicted)
密度
1.67±0.1 g/cm3 (20 ºC 760 Torr)
储存条件
Keep in dark place,Sealed in dry,2-8°C
酸度系数(pKa)
13.20±0.70(Predicted)
生物活性
Maribavir 是一种有效抑制野生型 pUL97 催化的组蛋白磷酸化，IC50 为 3 nM。Maribavir 可有效作用于 HCMV 和 Epstein-Barr 病毒 (EBV)。
体外研究
Maribavir is a potent inhibitor of the autophosporylation of the wild type and all the major Ganciclovir (GCV) resistant UL97 mutants analysed with a mean IC 50 of 35 nM. The M460I mutation results in hypersensitivity to Maribavir with an IC 50 of 4.8 nM. A Maribavir resistant mutant of UL97 (L397R) is functionally compromised as both a Ganciclovir kinase and a protein kinase (~ 10% of wild type levels). Enzyme kinetic experiments demonstrate that Maribavir is a competitive inhibitor of ATP with a K i of 10 nM. Maribavir (1263W94) inhibits viral replication in a dose-dependent manner, with IC 50 of 0.12±0.01 μM as measured by a multicycle DNA hybridization assay. The pUL97 protein kinase is strongly inhibited by Maribavir, with 50% inhibition occurring at 3 nM.
