中文名称:

羟嗪

中文同义词:

2-[2-[4-(4-氯苯基)苯甲基-1-哌嗪基]乙氧基]-乙醇;2-[2-[4-[(4-氯苯基)-苯甲基]哌嗪-1-基]乙氧基]乙醇;羟嗪杂质;羟嗪

英文名称:

Hydroxyzine

英文同义词:

1-(p-Chloro-a-phenylbenzyl)-4-[2-(2-hydroxyethoxy)ethyl)]piperazine;NSC 169188;1-(p-Chloro-α-phenylbenzyl)-4-[2-((2-hydroxyethoxy)ethyl)]piperazine;2-[2-[4-(p-Chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol;Ethanol, 2-[2-[4-(4-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]- (6CI);Ethanol, 2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]- (8CI);Hydroxyzine (base and/or unspecified salts);EQUIPOISE / HYDROXYZINE

CAS号:

68-88-2

分子式:

C21H27ClN2O2

分子量:

374.9

EINECS号:

200-693-1

相关类别:

医药原料;Aromatics;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

68-88-2.mol

熔点 

190°C

沸点 

250 °C(Press: 0.1 Torr)

密度 

1.1020 (rough estimate)

折射率 

1.5400 (estimate)

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

pKa 1.96± 0.05；7.40± 0.03(H2O,t =24.5±0.5)(Approximate)

水溶解性 

< 700 mg/mL

NIST化学物质信息

Hydroxyzine base(68-88-2)

EPA化学物质信息

Hydroxyzine (68-88-2)

生物活性

Hydroxyzine，一种苯二氮卓抗组胺剂 (antihistamine)，作为口服活性组胺 H1 受体 (histamine H1-receptor) 和血清素拮抗剂。Hydroxyzine 具有抗焦虑作用，可用于广泛性焦虑障碍的研究。

靶点

H 1 Receptor

H 1 Receptor

体外研究

Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.

体内研究

Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.

毒害物质数据

68-88-2(Hazardous Substances Data)

毒性

LD50 oral in rat: 840mg/kg