中文名称:

5-胆甾烯-3Β,25-二醇

中文同义词:

25-羟基胆甾醇;5-胆甾烯-3Β,25-二醇;25-羟基胆固醇;25-二醇;5-胆甾烯-3Β;25-羟基胆固醇 标准品;(3S,8S,9S,10R,13R,14S,17R)-17-[(R)-6-羟基-6-甲基-2-庚基]-10,13-二甲基-2,3,4,7,8,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊并[A]菲-3-醇

英文名称:

25-HYDROXYCHOLESTEROL

英文同义词:

25-HYDROXYCHOLESTEROL;3BETA,25-DIHYDROXY-5-CHOLESTENE;5-CHOLESTEN-3-BETA, 25-DIOL;5-CHOLESTENE-3BETA,25-DIOL;25-Hydroxycholesterol (not deuterated);Cholest-5-ene-3,25-diol, (3.beta.)-;5-cholestene-3β,25-diol;(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

CAS号:

2140-46-7

分子式:

C27H46O2

分子量:

402.65

EINECS号:

相关类别:

脂类;有机化学;化工原料;Hydroxycholesterol;Apoptosis;Inhibitors;Intermediates Fine Chemicals;Metabolites IMpurities;Pharmaceuticals;Steroids

Mol文件:

2140-46-7.mol

熔点 

177-179 °C

沸点 

513.1±23.0 °C(Predicted)

密度 

1.03±0.1 g/cm3(Predicted)

储存条件 

-20°C

储存条件 

room temp

溶解度 

chloroform: 50 mg/mL, clear, colorless to slightly yellow

酸度系数(pKa)

15.03±0.70(Predicted)

Merck 

13,4846

BRN 

3161259

InChIKey

INBGSXNNRGWLJU-ZHHJOTBYSA-N

生物活性

25-Hydroxycholesterol 是胆固醇的代谢产物，由巨噬细胞响应 Toll 样受体 (TLR) 激活而产生和分泌。25-Hydroxycholesterol 有效且选择性抑制 B 细胞产生 IgA，EC50 约为 65 nM。

靶点

Human Endogenous Metabolite

Human Endogenous Metabolite

体外研究

The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems.

危险品标志 

Xn

危险类别码 

20/21/22-36/37/38-48

安全说明 

26-36-45

WGK Germany 

3

海关编码 

29062990