英文同义词:
illudin M;(3S)-2,3-Dihydro-3α,6β-dihydroxy-2,2,4,6-tetramethylspiro[5H-indene-5,1-cyclopropan]-7(6H)-one;(3S,6R)-2,3-Dihydro-3,6-dihydroxy-2,2,4,6-tetramethylspiro[cyclopropane-1,5-[5H]inden]-7(6H)-one;Spiro[cyclopropane-1,5-[5H]inden]-7(6H)-one, 2,3-dihydro-3,6-dihydroxy-2,2,4,6-tetramethyl-, (3S,6R)-
熔点
120-122.5° (Matsumoto); mp 128-130° (McMorris)
沸点
452.4±45.0 °C(Predicted)
密度
1.24±0.1 g/cm3(Predicted)
酸度系数(pKa)
12.57±0.70(Predicted)
生物活性
Illudin M 是一种细胞毒性真菌倍半萜，可以从 Omphalotus olearius 蘑菇培养基中分离得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗肿瘤活性。
体外研究
Illudin M (0.01-10 μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitro.
Apoptosis Analysis
Cell Line: Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs)
Concentration: 0.01 μM, 1 μM, 10 μM
Incubation Time: 24 hours, 48 hours,72 hours, 96 hours, 120 hours
Result: Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%).
Cell Line:
Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs)
Concentration:
0.01 μM, 1 μM, 10 μM
Incubation Time:
24 hours, 48 hours,72 hours, 96 hours, 120 hours
Result:
Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%).
