中文名称:

叠氮-三聚乙二醇-对甲基苯磺酰酯

中文同义词:

叠氮-三聚乙二醇-对甲基苯磺酰酯

英文名称:

Azide-PEG3-Tos

英文同义词:

Azido-PEG3-Ots;2-(2-(2-Azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate;Azide-PEG3-Tos;N3-PEG3-Tos;Ethanol, 2-[2-(2-azidoethoxy)ethoxy]-, 4-methylbenzenesulfonate (ester);178685-33-1

CAS号:

178685-33-1

分子式:

C13H19N3O5S

分子量:

0

EINECS号:

相关类别:

分子砌块

Mol文件:

Mol File

生物活性

Azide-PEG3-Tos 是一种 PROTAC linker，属于 PEG 类，可用于合成PROTAC 分子。Azide-PEG3-Tos 也是一种不可降解 (non-cleavable) 的含 3 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

靶点

PEGs Non-cleavable

PEGs

Non-cleavable

体外研究

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.