尿酸
中文名称:
尿酸
中文同义词:
尿酸;2,6,8-三羟基嘌呤;尿酸,标准液;尿酸,参比液;2,6,8,-三羟基尿杂环;2,6,8,-三羟基嘌呤;尿酸(标准品);8-三羟基嘌呤
英文名称:
URIC ACID
英文同义词:
1H-Purine-2,6,8(3H)-trione,7,9-dihydro-;1H-Purine-2,6,8-triol;2,6,8-Trioxopurine;6,8(3H)-trione,7,9-dihydro-1H-Purine-2;7,9-Dihydro-1H-purine-2,6,8(3H)-trione;8(3h)-trione,7,9-dihydro-1h-purine-6;Purine-3,6,8(1H,3H,9H)-trione;PURINE-2,6,8(1H,3H,9H)-TRIONE
CAS号:
69-93-2
分子式:
C5H4N4O3
分子量:
168.11
EINECS号:
200-720-7
相关类别:
生化试剂;杂环砌块;小分子抑制剂;有机砌块;其他生化试剂;小分子抑制剂，天然产物;Heterocycles;Intermediates Fine Chemicals;Heterocycles, Metabolites Impurities, Pharmaceuticals, Intermediates Fine Chemicals;Inhibitors;酸;嘌呤;对照品;生化试剂-其他化学试剂;细胞生物学-细胞氧化应激;有机化工原料;中药对照品;化工原料;Metabolites Impurities;Pharmaceuticals
Mol文件:
69-93-2.mol
熔点
>300 °C (lit.)
沸点
297.02°C (rough estimate)
密度
1,9 g/cm3
折射率
1.9900 (estimate)
储存条件
Sealed in dry,2-8°C
酸度系数(pKa)
3.89(at 12℃)
形态
crystalline
颜色
White to off-white
气味 (Odor)
Odorless
水溶解性
Soluble in 1M sodium hydroxide solution. Slightly soluble in water. Insoluble in ether and alcohol.
Merck
14,9875
BRN
156158
稳定性
Stable. Incompatible with acids, bases, oxidising agents.
CAS 数据库
69-93-2(CAS DataBase Reference)
EPA化学物质信息
Uric acid (69-93-2)
简介
尿酸是嘌呤代谢的终末产物，体内总尿酸的80%由细胞核蛋白分解代谢产生，20%由摄入富含嘌呤的食物分解代谢产生。尿酸基本上以尿酸单钠盐的游离态形式存在于血液中，因此也称为血尿酸。
生物活性
Uric acid 是一种内源性抗氧化剂，可清除活性氧类化合物 (ROS)，包括单线态氧，氧自由基和过氧亚硝酸盐。
靶点
Human Endogenous Metabolite
Human Endogenous Metabolite
体外研究
Uric acid is an endogenous antioxidant that scavenges reactive oxygen species (ROS) including singlet oxygen, oxygen radicals, and peroxynitrite. Incubation with indomethacin significantly increases malondialdehyde (MDA) levels in Caco-2 cells compare to those not treated indomethacin. Incubation with both indomethacin and Uric acid significantly decreases MDA levels compare to those grown in the presence of indomethacin alone. Co-treatment of cells with indomethacin and Uric acid significantly decreases ROS levels compare to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both indomethacin and Uric acid is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity.
体内研究
When mice treated with indomethacin are concurrently administered Uric acid orally, ulcer areas are significantly reduced, in a Uric acid dose-dependent manner. Indomethacin increases the ratio of crypt depth to villous height in the ileum, while the ratio is significantly lower when mice are concurrently administered Uric acid orally. Administration of indomethacin also increases the histopathological score of tissue damage in the small intestine, while mice concurrently administered Uric acid orally has a significantly lower histopathological score. The ileal levels of malondialdehyde (MDA) in indomethacin-induced enteropathy model mice orally administered Uric acid are also significantly lower than the levels in mice administered indomethacin alone.
用途
用作分析试剂，也用于有机合成
用途
用作测定尿酸的标准液
生产方法
1.取干燥鸡粪悬浮于24倍量水中，加入适量氢氧化钙后静置。沉淀完全后分出上清液，沉淀中再加水，用硝酸调节pH值至3，静置至沉淀完全。分出上清液，沉淀物再悬浮在水中，以氢氧化钙调节pH值至12～12.5，过滤后滤液以硝酸调pH值至3，析出物过滤、干燥后即为尿酸粗品。
危险品标志
Xi
危险类别码
33-36/37/38
安全说明
24/25-36-26
WGK Germany
3
RTECS号
YU7050080
TSCA
Yes
海关编码
29339900
