土霉素二水合物
中文名称:
土霉素二水合物
中文同义词:
氧四环素/土霉素 二水合物;二水合土霉素;4-二甲氨基-1,4,4a,5,5a,6,11,12a-八氢-3,5,6,10,12,12a-六羟基-6-甲基-1,11-二氧代-并四苯-2-甲酰胺二水合物;土霉素/ 强力霉素;土霉素注射液;二水土霉素;地霉素;二水土霉素 标准品
英文名称:
Oxytetracycline dihydrate
英文同义词:
OXYTETRACYCLINE DIHYDRATE;4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide dihydrate;DOXYCYCLINE USP 23;OXYCYCLINE;DOXYCYCLINE HYCHLATE;DOXYCYCLINE HCL ( VETERINARY);OXYTETRACYCLINE HCL BP;DOXYCYCLINE HYDRATE BP98 USP23
CAS号:
6153-64-6
分子式:
C22H28N2O11
分子量:
496.46
EINECS号:
612-168-8
相关类别:
小分子抑制剂，天然产物;成药;生化试剂;抗生素;原料药;原料中间体-原料药;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;Amines;Chiral Reagents;Intermediates Fine Chemicals;Pharmaceuticals;EUTONYL;医药、农药及染料中间体;添加剂;FINISHED MEDICINE;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisSpectrum of Activity;L - ZAntibiotics;Mechanism of Action;Tetracyclines;Inhibitors
Mol文件:
6153-64-6.mol
熔点
181-182 °C
比旋光度
-216 º (c=1,0.1 M HCl)
储存条件
Sealed in dry,Room Temperature
溶解度
1 M HCl: 0.1 M yellow to yellow-orange, clear
形态
crystalline
颜色
yellow
水溶解性
slightly soluble
CAS 数据库
6153-64-6(CAS DataBase Reference)
EPA化学物质信息
Oxytetracycline dihydrate (6153-64-6)
生物活性
Oxytetracycline Dihydrate 是一种处方抗生素，干扰细菌产生必需蛋白质的能力。
靶点
HSV-1
Bacterial
Human Endogenous Metabolite
HSV-1
Bacterial
体外研究
Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes.
体内研究
The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis , the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter.
For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days.
用途
阻止aminoacyl-tRNA结合到30S亚单元上，抑制蛋白质合成（延长期）。 抗菌谱: 革兰氏阴性和阳性菌
危险品标志
Xn,Xi
危险类别码
63-36-36/37/38
安全说明
22-24/25-36/37/39-26-36
WGK Germany
3
海关编码
29413000
