中文名称:

PROPARGYL-PEG8-NH2

中文同义词:

丙炔基-八聚乙二醇-氨基;丙炔-八聚乙二醇-胺;丙炔-八聚乙二醇-氨基;炔基八聚乙二醇氨基;炔基-八聚乙二醇-氨基,PROPARGYL-PEG8-AMINE;炔基-八聚乙二醇-氨基,PROPARGYL-PEG8-AMINE,PROPARGYL-PEG8-NH2

英文名称:

Propargyl-PEG8-amine

英文同义词:

Propargyl-PEG8-amine;HC≡C-CH2-PEG8-NH2;Propyne-PEG8-amine;Alkyne-PEG8-NH2;PROPARGYL-PEG8-NH2;3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yn-1-amine;1196732-52-1

CAS号:

1196732-52-1

分子式:

C19H37NO8

分子量:

407.5

EINECS号:

相关类别:

小分子PEG

Mol文件:

1196732-52-1.mol

生物活性

Propargyl-PEG8-NH2 (compound 3b) 是一种 PROTAC 连接桥，属于 PEG 类。Propargyl-PEG8-NH2 可用于合成一系列 PROTAC 分子。Propargyl-PEG8-NH2 是一种不可降解 (non-cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

靶点

Non-cleavable PEGs

Non-cleavable

PEGs

体外研究

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.