中文同义词:
头孢他啶杂质D(EP);头孢他啶EP杂质E;头孢他啶叔丁酯;头孢他啶杂质5
英文名称:
1-[[(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-[[2-(1,1-diMethylethoxy)-1,1-diMethyl-2-oxoethoxy]iMino]acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]pyridiniuM Inner Salt
英文同义词:
1-[[(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-[[2-(1,1-diMethylethoxy)-1,1-diMethyl-2-oxoethoxy]iMino]acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]pyridiniuM Inner Salt;CeftazidiMe t-Butyl Ester;Ceftazidime EP Imp E;Ceftazidime Impurity D(EP);Ceftazidime impurity 5/Ceftazidime EP Impurity E/(6R,7R)-7-[[(2Z)-2-(2-aminothiazol-4-yl)-2-[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]acetyl]amino]-8-oxo-3-[(1-pyridinio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Ceftazidime tert-butyl ester;Ceftazidime Ep Impurity E;(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
相关类别:
中间体;杂质;中间体原料;Sulfur Selenium Compounds;Chiral Reagents, Heterocycles, Impurities, Pharmaceuticals, Intermediates Fine Chemicals, Sulfur Selenium Compounds;Chiral Reagents;Heterocycles;Impurities;Intermediates Fine Chemicals;Pharmaceuticals
简介
在头孢他啶的制备过程中最有可能产生该杂质是在合成头孢他啶叔丁酯工艺环节或头孢他啶活性酯原料中有微量该杂质。
制备
一种头孢他啶叔丁酯的制备方法：在洁净干燥的四口反应瓶中加入三氯甲烷520ml，加入叔丁醇30ml，降温至0-5℃。加入7-APCA70g，他啶活性酯105g，控制温度滴加三乙胺，调PH至7.0-9.0。控温0-10℃反应20-24小时。反应毕，加入纯水150ml，搅拌1-2小时，分出三氯甲烷。药液中滴入异丙醇析出头孢他啶叔丁酯，0-10℃搅拌养晶2小时。抽滤，用异丙醇洗涤，烘干后得头孢他啶叔丁酯干品。重量产率：145％，纯度98.9％。
