中文名称:

强啡肽 A (1-13)

中文同义词:

强啡肽 A (1-13);强啡肽A(1-13),猪, BR;醋酸强啡肽A;猪DYNORPHIN A (1-13)肽;醋酸强啡肽A(1-13);DYNORPHIN A (1-13)|强啡肽 A (1-13);醋酸强啡肽;醋酸强啡肽 DYNORPHINA(1-13)ACETATE

英文名称:

Dynorphin A (1-13)

英文同义词:

TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS;TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS 5ACOH 6H2O;TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS PORCINE;YGGFLRRIRPKLK;L-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS;DYNORPHIN A PORCINE FRAGMENT 1-13;DYNORPHIN A(HUMAN, 1-13);DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE)

CAS号:

72957-38-1

分子式:

C75H126N24O15

分子量:

1603.95

EINECS号:

相关类别:

多肽;医药原料药;定制;药物多肽;Opioid receptor and opioid-like receptor;peptide;DynorphinsPeptides for Cell Biology;Dynorphins;Neuropeptides;Opioid Peptides

Mol文件:

72957-38-1.mol

密度 

1.39±0.1 g/cm3(Predicted)

RTECS号

JV7436666

储存条件 

Inert atmosphere,Store in freezer, under -20°C

酸度系数(pKa)

3.31±0.10(Predicted)

生物活性

Porcine dynorphin A (1-13) 是一个有效的内源性阿片受体 (κ opioid receptor) 激动剂，在生理浓度下它有镇痛作用。

靶点

Κ opioid receptor.

体内研究

Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca 2+ ] i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time.

WGK Germany 

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