中文名称:

辛伐他汀钠盐

中文同义词:

辛伐他汀杂质A;羟基辛伐他汀酸钠;辛伐他汀羟基酸钠盐-D6;辛伐他汀钠盐;辛伐他汀羟基酸钠盐;辛伐他汀相关化合物A(USP);辛伐他汀钠;辛伐他汀羟基酸钠

英文名称:

SIMVASTATIN, SODIUM SALT

英文同义词:

SIMVASTATIN HYDROXY ACID SODIUM SALT;SIMVASTATIN, SODIUM SALT;sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate;Simvastatin hydroxyl acid sodium salt-d6;IMp. A (EP) as SodiuM Salt: (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-DiMethylbutanoyl)oxy]-2,6-diMethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid SodiuM Salt (Tenivastatin SodiuM Salt;Simvastatin Impurity as Sodium Salt;Simvastati;Simvastatin EP Impurity A Sodium Salt

CAS号:

101314-97-0

分子式:

C25H39NaO6

分子量:

458.56

EINECS号:

相关类别:

168- 辛伐他汀;杂质对照品

Mol文件:

Mol File

形态

White powder solid.

生物活性

Simvastatin hydroxy acid sodium (Tenivastatin sodium; Simvastatin Impurity A sodium) 是辛伐他汀 (HY-17502) 活性水解代谢物。Simvastatin 是一种竞争性的 HMG-CoA 还原酶抑制剂， Ki 值为 0.2 nM。

体外研究

Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts.Simvastatin sodium (100 μM) inhibits the Na + /H + antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene.

体内研究

Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia.