中文名称:

Azido-PEG6

中文同义词:

叠氮-六乙二醇-羟基;叠氮-六聚乙二醇;叠氮-六聚乙二醇-羟基;AZIDO-PEG6-ALCOHOL,N3-PEG6-OH

英文名称:

Azido-PEG6

英文同义词:

azido-PEG6-OH;2[-2-(2-{2-[2-(2-hydroxyethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]- ethyl azide;Azido-PEG6;Azido-PEG6-alcohol;N3-PEG6-OH;AZIDO-PEG6-HYDROXY;3,6,9,12,15-Pentaoxaheptadecan-1-ol, 17-azido-;86770-69-6

CAS号:

86770-69-6

分子式:

C12H25N3O6

分子量:

307.35

EINECS号:

相关类别:

基准试剂;其它

Mol文件:

86770-69-6.mol

生物活性

Azido-PEG6-alcohol 是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。Azido-PEG6-alcohol 也是一种不可降解 (non-cleavable) 的含 6 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

靶点

PEGs Non-cleavable

PEGs

Non-cleavable

体外研究

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.