Beta-榄香烯
中文名称:
Beta-榄香烯
中文同义词:
B-榄香烯;Β-ELEMENE;BETA-榄香烯;Β-榄香烯 标准品;Β-榄香烯
英文名称:
BETA-ELEMENE
英文同义词:
C15 H24, Cyclohexan, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-;levo-beta-Elemene;β-Elemen;(1S,2S,4R)-1-Ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane;Cyclohexane,1-ethenyl-1-Methyl-2,4-bis(1-Methylethenyl)-, (1S,2S,4R)-;(1S,2S,4R)-(?)-2,4-Diisopropenyl-1-methyl-1-vinylcyclohexane;(-)-beta-Elemene analytical standard;β-Elemene (10mg/ml in ethanol)
CAS号:
515-13-9
分子式:
C15H24
分子量:
204.35
EINECS号:
相关类别:
标准品;标准品;化工原料;API
Mol文件:
515-13-9.mol
沸点
252℃
密度
0.862
闪点
98℃
储存条件
2-8°C
形态
neat
BRN
2207781
InChIKey
OPFTUNCRGUEPRZ-RBSFLKMASA-N
生物活性
β-Elemene ((-)-β-Elemene, Levo-β-elemene) 是一种从草本Curcuma Rhizoma中提取的倍半萜烯类化合物，具有抗肿瘤的活性。β-Elemene 可以抑制细胞增殖，阻止细胞周期，并诱导细胞凋亡或自噬。
体外研究
β-Elemene (0-200 µg/ml; 24 hours) shows IC 50 values of 72.8 µg/ml; 47.4 µg/ml; 61.5 µg/ml; 3.661 µg/ml; 68 µg/ml; 72.12 µg/ml; 37.894 µg/ml and 37.703 µg/ml for SV-HUC-1, T24, 5637, TCCSUP, J82,UMUC-3,RT4, and SW780 cells, respectively. β-Elemene (0-75 µg/ml; 24 hours) decreases cell number from 50 µg/ml and is notably decreased at 75 µg/ml, induces dose-dependent G1-phase arrest in T24cells and significantly reduces the percentage of cells in the S-phase . β-Elemene (50 µg/ml; 12 hours) downregulates the expression levels of p-STAT3 and the cell cycle-related proteins cyclin D1, CDK4 and CDK6, and upregulates p21 and p27expression in T24 cells . β-Elemene (50 µg/ml; 24 hours) enhances cisplatin-induced apoptosis by activating the ROS-AMPK signaling pathway.
Cell Viability Assay
Cell Line: T24, 5637, TCCSUP, J82, UM-UC-3, RT4 and SW780 cells
Concentration: 0, 6.25, 12.5, 25, 50, 100, 150 and 200 µg/ml
Incubation Time: 24 hours
Result: Inhibited the proliferation of RT4, SW780, J82, UMUC-3, TCCSUP, 5637 and T24 human bladder cancer cells and SV-HUC-1 human urothelial cells.
Cell Cycle Analysis
Cell Line: T24 and 5637 cells
Concentration: 0, 25, 50 and 75 µg/ml
Incubation Time: 24 hours
Result: Induced the percentage of cells in the S-phase as a dose-dependent manner.
Western Blot Analysis
Cell Line: T24 cells
Concentration: 50 µg/ml
Incubation Time: 24 hours
Result: Downregulated p-STAT3 and cell cycle-related proteins.
Cell Line:
T24, 5637, TCCSUP, J82, UM-UC-3, RT4 and SW780 cells
Concentration:
0, 6.25, 12.5, 25, 50, 100, 150 and 200 µg/ml
Incubation Time:
24 hours
Result:
Inhibited the proliferation of RT4, SW780, J82, UMUC-3, TCCSUP, 5637 and T24 human bladder cancer cells and SV-HUC-1 human urothelial cells.
Cell Line:
T24 and 5637 cells
Concentration:
0, 25, 50 and 75 µg/ml
Incubation Time:
24 hours
Result:
Induced the percentage of cells in the S-phase as a dose-dependent manner.
Cell Line:
T24 cells
Concentration:
50 µg/ml
Incubation Time:
24 hours
Result:
Downregulated p-STAT3 and cell cycle-related proteins.
危险类别码
66
WGK Germany
3
RTECS号
GU9660000
