中文名称:
4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯
中文同义词:
4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯
英文同义词:
JZL 195;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester;CS-1586;JZL-195;JZL 195;JZL195;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester
相关类别:
小分子抑制剂;小分子抑制剂，天然产物;医药;Inhibitors;API
沸点
581.8±50.0 °C(Predicted)
密度
1.303±0.06 g/cm3(Predicted)
储存条件
Sealed in dry,Store in freezer, under -20°C
溶解度
DMSO: ≥5mg/mL at warmed
酸度系数(pKa)
6.13±0.10(Predicted)
生物活性
JZL195是有效的FAAH和MAGL抑制剂，IC50分别为2 nM和4 nM。
靶点
Target Value
FAAH
() 2 nM
MAGL
() 4 nM
体外研究
JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC 50 values of 13 and 19 nM, respectively).
JZL195 inhibits rat and human FAAH and MAGL enzymes with IC 50 values in the range of ≈10-100 nM based on competitive ABPP assays.
体内研究
JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay.
Animal Model: Male C57BL/6J mice
Dosage: 20 mg/kg
Administration: Intraperitoneal injection
Result: Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone.
Animal Model:
Male C57BL/6J mice
Administration:
Intraperitoneal injection
Result:
Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone.
危险品运输编号
UN 3077 9 / PGIII
