中文名称:

DBCO-PEG5-NHS ESTER

中文同义词:

二苯基环辛炔-五聚乙二醇-NHS酯;二苯并环辛炔-五聚乙二醇-NHS酯;DBCO-PEG5-NHS ESTER,二苯基环辛炔-五乙二醇-琥珀酰亚胺酯;二苯并环辛炔-五聚乙二醇-琥珀酰亚胺酯

英文名称:

DBCO-PEG5-NHS ester

英文同义词:

4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester

CAS号:

2144395-59-3

分子式:

C36H43N3O11

分子量:

693.74

EINECS号:

相关类别:

Mol文件:

2144395-59-3.mol

生物活性

DBCO-PEG5-NHS ester 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类，用于合成一系列 PROTAC 分子。DBCO-PEG5-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

靶点

Cleavable Alkyl/ether PEGs

Cleavable

Alkyl/ether

体外研究

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.