头孢唑啉

中文名称:

头孢唑啉

中文同义词:

头孢唑啉(标准品);(6R,7R)-3-[(5-甲基-1,3,4-噻二唑-2-基)硫甲基]-8-氧代-7-[[2-(四唑-1-基)乙酰]氨基]-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸;头孢唑啉,唑啉头孢菌素;头孢拉定V;头孢唑林;头孢菌素Ⅴ;头孢唑啉;先锋霉素Ⅴ

英文名称:

Cefazolin

英文同义词:

CEFAZOLIN;CEFAZOLIN ACID;(6r-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[(1h-tetr;5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,3-(((5-methyl-1,3,4-thia;(6R,7R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[1-oxo-2-(1-tetrazolyl)ethyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;7-(1-(1h-)-tetrazolylacetamido)-3-[2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl]d;azol-1-yl)acetyl]-amino]-5-thia-1-azabicylo;cefamezin

CAS号:

25953-19-9

分子式:

C14H14N8O4S3

分子量:

454.51

EINECS号:

247-362-8

相关类别:

其他类抗生素;医药中间体;医药、农药及染料中间体;头孢唑林钠杂质优势供应;医药原料

Mol文件:

25953-19-9.mol

熔点

198-200 C

密度

2.01±0.1 g/cm3(Predicted)

形态

neat

酸度系数(pKa)

pKa 2.15 (Uncertain)

CAS 数据库

25953-19-9(CAS DataBase Reference)

生物活性

Cefazolin是一种半合成的头孢菌素，具有广谱的抗菌作用，抑制细菌细胞壁的合成。它可达到高血清水平，通过尿液快速排泄。

靶点

Antibiotic

体外研究

Cefazolin (50-300 μg/mL; 6 or 24 hours) has a direct anti-inflammatory effect on C8-B4 cells stimulated by LPS (1 μg/mL). Cell Viability Assay Cell Line: Mouse C8-B4 microglial cells Concentration: 50, 100, 150, 200, 250, and 300 μg/mL Incubation Time: 6 or 24 hours Result: Inhibited proinflammatory cytokine production. Inhibited IL-6 production at 50 and 100 μg/mL.

Cell Line:

Mouse C8-B4 microglial cells

Concentration:

50, 100, 150, 200, 250, and 300 μg/mL

Incubation Time:

6 or 24 hours

Result:

Inhibited proinflammatory cytokine production. Inhibited IL-6 production at 50 and 100 μg/mL.

体内研究

Cefazolin (300 mg/kg; injected intraperitoneally 1 h before surgery and then once per day for 5 days after surgery) can attenuate surgery-induced post-operative memory and learning impairment in mice. Cefazolin alone may induce cognitive dysfunction possibly by transient gut dysbiosis in mice without surgery. Animal Model: Six- to 8-week-old CD-1 male mice (weighing 31-36 g) Dosage: 300-500 mg/kg Administration: 10 mg in 0.1 mL was intraperitoneally injected 30 min before surgery and then once every day for 5 days. Result: Improved learning and memory after surgery and might impair learning and memory in mice without surgery.

Animal Model:

Six- to 8-week-old CD-1 male mice (weighing 31-36 g)

Dosage:

300-500 mg/kg

Administration:

10 mg in 0.1 mL was intraperitoneally injected 30 min before surgery and then once every day for 5 days.

Result:

Improved learning and memory after surgery and might impair learning and memory in mice without surgery.

化学性质

针状晶体。熔点198-200℃（分解），易溶于DMF、吡啶，溶于丙酮、乙醇，微溶于甲醇，不溶于氯仿、苯、醚。其钠盐（[27164-46-1]）为白色或微黄色粉末。难溶于甲醇、乙醇，不溶于丙酮、氯仿。干燥时稳定，水溶液的稳定性较差。

用途

半合成广谱头孢菌素。抗菌机理、抗菌谱、适应症均与头孢噻吩相似。对革兰氏性菌弱于后者。但对革兰氏阴性菌比后者强得多，尤其对肺炎杆菌有效，对大肠杆菌比头孢噻吩强，对肺炎球菌作用仅次于青霉素而优于其他抗生素。血清蛋白结合率74-86%。在肝、肾、心、脾、肺、肌肉等组织中浓度高。用于上述器官敏感菌感染。特别是用于一些严重感染。临床治疗呼吸系统及泌尿系感染疗效显著。

用途

为半合成广谱头孢菌素，抗菌机理、抗菌谱、适应性均与头孢噻吩相似

生产方法

以头孢菌素C为原料制得。

危险品标志

危险类别码

20/21/22-36/37/38

安全说明

26-36

WGK Germany

海关编码

2941906000