D-谷氨酰胺
中文名称:
D-谷氨酰胺
中文同义词:
D-谷氨酰酸;D-氨羰基丁氨酸;D-麸氨酰胺;D-谷氨酸酰胺;D-谷胺酰胺;谷氨酸盐杂质;D-谷氨酸盐;D-谷氨酸-5-酰胺
英文名称:
D-Glutamine
英文同义词:
D(-)-GLUTAMIC ACID-5-AMIDE;D-GLUTAMIC ACID 5-AMIDE;D-GLUTAMINIC ACID 5-AMIDE;D(-)-GLUTAMINE;D-GLUTAMINE;D-GLUTAMINE extrapure;D-2-Aminoglutaramic acid, D-Glutamic acid 5-amide;Citric Acid, Monohydrate, Crystal, Reagent
CAS号:
5959-95-5
分子式:
C5 H10 N2 O3
分子量:
146.14
EINECS号:
673-968-0
相关类别:
细胞信号和神经生物学;膦配体;氨基酸类;化学试剂;中药对照品;对照品;氨基酸;氨基酸及其衍生物;生化试剂;细胞生物学;其他生化试剂;保护氨基酸;非天然氨基酸;医药中间体、氨基酸衍生物;天然氨基酸极其衍生物;小分子抑制剂，天然产物;生化试剂-氨基酸类;医用原料;Amino ACIDS SERIES;pharmacetical;chiral;Glutamine [Gln, Q];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;Amino Acids and Derivatives;amino acid;Inhibitors;医药原料;D-氨基酸
Mol文件:
5959-95-5.mol
熔点
184-185 °C
比旋光度
-32 º (589nm, c=10, N HCl)
沸点
265.74°C (rough estimate)
密度
1.3394 (rough estimate)
折射率
-33 ° (C=5, 5mol/L HCl)
储存条件
Keep in dark place,Inert atmosphere,Room temperature
形态
Powder
酸度系数(pKa)
2.27±0.10(Predicted)
颜色
White
水溶解性
42.53g/L(temperature not stated)
BRN
1723796
InChIKey
ZDXPYRJPNDTMRX-GSVOUGTGSA-N
CAS 数据库
5959-95-5(CAS DataBase Reference)
生物活性
D-Glutamine 是可渗透细胞的谷氨酰胺 (Glutamine) 的 D 型立体异构体。
靶点
Human Endogenous Metabolite
Human Endogenous Metabolite
体外研究
Glutamine is a key amino acid in the central nervous system (CNS), playing an important role in the glutamate/GABA-Glutamine cycle (GGC). In the GGC,Glutamine is transferred from astrocytes to neurons, where it will replenish the inhibitory and excitatory neurotransmitter pools. D-Glutamine has been used to study its role in conferring protection against acetaldehyde-induced disruption of barrier function in Caco-2 cell monolayer. Role of L-Glutamine in the protection of intestinal epithelium from acetaldehyde-induced disruption of barrier function is evaluated in Caco-2 cell monolayer. L-Glutamine reduced the acetaldehyde-induced decrease in transepithelilal electrical resistance and increase in permeability to inulin and lipopolysaccharide in a time- and dose-dependent manner; D-Glutamine, L-aspargine, L-arginine, L-lysine, or L-alanine produced no significant protection. D-Glutamine also fails to influence the acetaldehyde-induced decrease in TER and increase in inulin flux. D-Glutamine or glutaminase inhibitor by themselves did not influence TER or inulin flux in control or acetaldehyde-treated cell monolayers. Lack of effect of D-Glutamine in protection from acetaldehyde indicates that the L-Glutamine-mediated protection is stereospecific.
用途
是一种药用氨基酸，用于治疗胃和十二指肠溃疡和幼儿智力低下等症，也是治疗白血病药物的中间体。
危险品标志
Xi
危险类别码
36/37/38
安全说明
36/37/39-26-27-24/25
WGK Germany
3
海关编码
29241900
