中文同义词:
多西拉敏琥珀酸;N,N-二甲基-2-[1-苯基-1-(2-吡啶)乙氧基]乙胺琥珀酸盐;琥珀酸多西拉敏;多西拉敏琥珀酸酯;琥珀酸多西拉敏(标准品);多西拉敏琥珀酸盐;抗敏安系统适用性 EP标准品;琥珀酸多西拉敏 EP标准品
英文名称:
Doxylamine succinate
英文同义词:
LABOTEST-BB LT00244822;DOXYLAMINE SUCCINATE;DOXYLAMINE SUCCINATE SALT;2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)-pyridinsuccinate(1;2-(alpha-(2-dimethylaminoethoxy)-alpha-methylbenzyl)pyridinesuccinate;2-dimethylaminoethoxyphenylmethyl-2-picolinesuccinate;alsadorm;decapryn
相关类别:
小分子抑制剂;阿普斯特中间体;医药原料;化学中间体;API;DECAPRYN;Other APIs;Antagonists;Histaminergics;Neurotransmitters;Amines;Aromatics;Heterocycles;Intermediates Fine Chemicals;Neurochemicals;Pharmaceuticals
溶解度
Very soluble in water, freely soluble in ethanol (96 per cent).
稳定性
Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases.
InChIKey
KBAUFVUYFNWQFM-UHFFFAOYSA-N
CAS 数据库
562-10-7(CAS DataBase Reference)
(IARC)致癌物分类
3 (Vol. 79) 2001
EPA化学物质信息
Doxylamine succinate (1:1) (562-10-7)
生物活性
Doxylamine succinate竞争性抑制组胺H1受体，具有镇静和抗胆碱作用。
靶点
Target Value
Histamine H1 receptor
体内研究
Doxylamine（以琥珀酸盐形式）对微粒体酶活性和血清甲状腺激素水平的影响在B6C3F1小鼠体内进行了考察，食物摄取7天或15天(饮食中含量0, 40, 375, 750, or 1500 ppm, 以游离碱doxylamine形式)。该结果显示，在B6C3F1小鼠体内，doxylamine是肝微粒体细胞色素P450Â的巴比妥类诱导剂，并符合doxylamine增加了参与T4代谢的肝酶活性的假说。
危险类别码
22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
危险品运输编号
UN1230 - class 3 - PG 2 - Methanol, solution
毒性
LD50 in mice, rabbits (mg/kg): 470, 250 orally; 62, 49 i.v.; in mice, male rats, female rats (mg/kg): 460, 440, 445 s.c. (Brown, Werner)
