中文名称:

阿维菌素 B1a

中文同义词:

阿维菌素原料药;阿巴汀;爱弗菌素;克螨灵;齐螨素;阿维菌素 B1a;依维菌素杂质1;伊维菌素EP杂质A

英文名称:

Avermectin B1a

英文同义词:

avermectin b1a;ABAMECTIN BETA-CYPERMETHRIN 1%;ABERMECTINS;AverMectin A1a,5-O-deMethyl-;Ivermectin Impurity 1(Ivermectin EP Impurity A);5-o-demethyl-avermectin a1;5-O-DemethylAvermectin A1a;Antibiotic C-076B1a

CAS号:

65195-55-3

分子式:

C48H72O14

分子量:

873.09

EINECS号:

265-610-3

相关类别:

兽用原药;微生物代谢物;化工原料;农业原料;原料;有机化工;中间体;原料;API原料药-兽药原料药;原药中间体

Mol文件:

65195-55-3.mol

沸点 

940.9±65.0 °C(Predicted)

密度 

1.24±0.1 g/cm3(Predicted)

酸度系数(pKa)

12.42±0.70(Predicted)

EPA化学物质信息

Avermectin B1a (65195-55-3)

生物活性

Avermectin B1a 是一种抗寄生虫剂，能够使线虫瘫痪。

体外研究

[ 3 H]AVM B1a preferentially binds to synaptic membranes from several regions of rat brain. [ 3 H]AVM B1a specific binding to intact monolayers of granule cells increases rapidly with time of incubation and reaches equilibrium after approximately 20 min at 24°C. Higher concentrations of [ 3 H]AVM B1a leads to markedly greater nonspecific binding, 60% at 25 nM. Various AVM analogs also produce concentration-dependent inhibition of [ 3 H]AVM B1a binding in intact cerebellar neurons. AVM B1a and moxidectin are similar in potency (IC 50 values, 120 and 126 nM, respectively). AVMB1a-stimulated chloride efflux from mouse brain synaptic vesicles results from the activation of GABA-insensitive chloride channels and that this action is distinct from their previously documented effects on GABA-gated chloride channels in mouse brain preparations.

体内研究

Bacteria are significantly inhibited when the AVM B1a concentration is higher than 83.3 mg/kg, while fungi are less impaired in soil. Soil respiration is also inhibited by high concentration AVM B1a, which differs with soil types. The half lethal dosage (LD 50 ) of AVM B1a to soil earthworm is estimated as 4.63 mg × cm 2 in filter paper contact test, and as 24.13 and 17.06 mg/kg, respectively after treated 7 and 14 days in artificial soil. Iin artificial soil, the LC50 of AVM B1a on earthworms are 24.1 mg/kg and 17.1 mg/kg, respectively, for 7 and 14 days. About 80.0% and 94.8% of the accumulated AVM B1a are eliminated respectively in two groups within 1 day after they are exposed to AVM B1a-free soil, but a trace amount of AVM B1a is found for a relative long time in earthworms.

类别

有毒物品

毒性分级

高毒

急性毒性

口服-大鼠 LD20: 10 毫克/公斤; 口服-小鼠 LD50: 19 毫克/公斤

可燃性危险特性

可燃; 燃烧产生刺激烟雾

储运特性

通风低温干燥

灭火剂

干粉,泡沫,沙土,二氧化碳, 雾状水

危险品运输编号 

2588

HazardClass 

6.1(a)

PackingGroup 

II

毒性

LD20 orl-rat: 10 mg/kg JAFCAU 32,94,84