中文同义词:
L-O-磷酸丝氨酸;L-2-氨基-3-羟基丙酸3-磷酸;L-丝氨酸O-磷酸;O-磷酸-L-丝氨酸;L-丝氨酸O-型磷酸;L-2-氨基-3-羟基丙酸三磷酸;L-O-磷酸丝氨酸;磷酸化丝氨酸
英文同义词:
L-O-PHOSPHOSERINE;L-SERINE-O-PHOSPHATE;L-PHOSPHOSERINE;H-SER(PO3H2)-OH;PHOSPHATIDYLETHANOLAMINE(EGG)(RG);O-Phosho-L-serine;O-Phosphorylserine;Phospho-L-serine
相关类别:
酯;小分子抑制剂;氨基酸衍生物;Glutamate receptor;Amino Acids;Biochemistry;Biological-modified Amino Acids
比旋光度
[α]D20 +14～+18°(c=5,dil.HCl)
沸点
475.4±55.0 °C(Predicted)
密度
1.809±0.06 g/cm3(Predicted)
溶解度
H2O: 50 mg/mL hot, clear, colorless to slightly yellow
酸度系数(pKa)
pK1:2.08;pK2:5.65;pK3:9.74 (25°C)
InChIKey
BZQFBWGGLXLEPQ-UWTATZPHSA-N
CAS 数据库
407-41-0(CAS DataBase Reference)
生物活性
O-Phospho-L-serine 是 L-serine 合成过程中的直接前体物质，是第三组 mGluR (mGluR4，mGluR6，mGluR7 和 mGluR8) 的激动剂，O-Phospho-L-serine 同时为 mGluR1 和 mGluR2 的拮抗剂。
体外研究
O-Phospho-L-serine (l-SOP) weakly binds to mGluR1, and antagonizes the effects of l-glutamate. l-SOP activates the group III receptors (mGluR4, mGluR6, mGluR7, and mGluR8), but mGluR7 has much lower affinity for l-SOP than the other group III receptors and also displays lower efficacy for both ligands. O-Phospho-L-serine (l-SOP) generates enhanced intracellular calcium responses in mGluR4 transfected cells. l-SOP inhibits the l-glutamate mediated mGluR1 response, with a K i of 1 mM; l-SOP displays a substantially more potent inhibition of mGluR2 activation, with a K i of 1 μM, three orders-of-magnitude more potent than for mGluR1. l-SOP induces membrane potential changes in HEK/TRPC4 cells transfected with mGluR4 or mGluR6. l-SOP induces TRPC4β activation mediated by Gα i/o proteins. O-Phospho-L-serine (L-SOP) inhibits Müller glia proliferation, without affecting light-induced photoreceptor cell death. L-SOP disrupts Müller glia proliferation subsequent to or in parallel with the activation of ascl1a and stat3 expression in the light-damaged retina. L-SOP inhibits cone cell regeneration in the light-damaged retina.
